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Research
The genetic basis of metastasis is still unclear because metastases carry individual karyotypes and phenotypes, rather than consistent mutations, and are rare compared to conventional mutation. There is howeve...
Molecular Cytogenetics 2016 9:90
Published on: 16 December 2016
Review
Oral cancer is one of the most common malignant lesions of the head and neck. This cancer is an aggressive and lethal disease with no significant improvements in the overall survival in the last decades. Moreo...
Molecular Cytogenetics 2016 9:85
Published on: 23 November 2016
Research
Intrachromosomal amplification of chromosome 21 (iAMP21) results from breakage-fusion-bridge cycles and chromothripsis is a distinct marker of a subgroup of B cell acute lymphoblastic leukemia (B-ALL) cases as...
Molecular Cytogenetics 2016 9:84
Published on: 21 November 2016
Case Report
Constitutional translocations between sex chromosomes are rather rare in humans with breakpoints at Xp11 and Yq11 as the most frequent. Breakpoints on the short arm of the Y chromosome form one subgroup of t(X...
Molecular Cytogenetics 2016 9:67
Published on: 31 August 2016
Methodology
Cytogenetic abnormalities are important prognostic markers in plasma cell myeloma (PCM) and detection is routinely performed by interphase fluorescence in-situ hybridization (FISH) with a panel of probes after...
Molecular Cytogenetics 2016 9:63
Published on: 16 August 2016
Research
Sex chromosome loss (SCL), including loss of an X chromosome (-X) in females and loss of the Y chromosome (-Y) in males, resulting in a karyotype of 45,X, rarely occurs in patients post an allogeneic hematopoi...
Molecular Cytogenetics 2016 9:62
Published on: 8 August 2016
Short report
Despite progression in treatment of gastric cancer, prognosis of patients remains poor, in part due to the low rate of diagnosis during its early stages. This paradigm implies the necessity to identify molecul...
Molecular Cytogenetics 2016 9:52
Published on: 29 June 2016
Case Report
BCR-ABL1 fusion proteins contain constitutively active tyrosine kinases that are potential candidates for targeted therapy with tyrosine kinase inhibitors such as imatinib in chronic m...
Molecular Cytogenetics 2016 9:47
Published on: 27 June 2016
Case Report
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. Based on literature reports of limited cases, over 50 % of BPDCN have chromosomal abnormalities, but no single chromosomal...
Molecular Cytogenetics 2016 9:23
Published on: 27 February 2016
Research
Wilms tumor (WT) has a not completely elucidated pathogenesis. DNA copy number alterations (CNAs) are common in cancer, and often define key pathogenic events. The aim of this work was to investigate CNAs in o...
Molecular Cytogenetics 2016 9:20
Published on: 24 February 2016
Short report
Diffuse astrocytomas are characterized by their highly variable biological behavior. The possibility that tumors develop novel aberrations, with relevant biological properties, is often neglected. In this stud...
Molecular Cytogenetics 2016 9:13
Published on: 9 February 2016
Research
Deletion of 13q14 is the most common cytogenetic change in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and is detected in about 50 % of patients by fluorescence in situ hybridization (FIS...
Molecular Cytogenetics 2016 9:1
Published on: 6 January 2016
