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Thematic Series: Chromosomal imbalances and cancer

Chromosomal imbalances have been known as common features of cancer genomes for a long time. However, we have started to comprehend their causative link to tumorigenesis only recently. Chromosomal instability – as a process leading to abnormal chromosome content and heterogeneity – has been widely researched and increasingly referred to as driving force behind malignant transformation and defining factor for cancer evolution.

The aim of this thematic series was to bring together the latest research findings and conceptual developments in the field of chromosomal imbalances and cancer, publishing original research papers on the complex interplay of chromosomal instability and aneuploidy in cancerous and pre-cancerous lesions, and papers exploring potential translational aspects.

Guest Editor: Emanuela V. Volpi, University of Westminster

Publication: Closed for additional submissions


  1. Authors: Maj A Hultén, Suketu D Patel, Maira Tankimanova, Magnus Westgren, Nikos Papadogiannakis, Anna Maria Jonsson and Erik Iwarsson

    Content type: Research

Featured article: Aneuploid abortion correlates positively with MAD1 overexpression and miR-125b down-regulation

Juan Zhao, Hui Li, Guangxin Chen, Lijun Du, Peiyan Xu, Xiaoli Zhang, Min Xie, Tiansheng Cao & Haibo Li 
Molecular Cytogenetics, volume 14, Article number: 22 (2021)

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

Aims and scope

Molecular Cytogenetics encompasses all aspects of chromosome biology and the application of molecular cytogenetic techniques in all areas of biology and medicine, including structural and functional organization of the chromosome and nucleus, genome variation, expression and evolution, chromosome abnormalities and genomic variations in medical genetics and tumor genetics.  The journal is divided into the following sections:

  • Cancer genetics
  • Clinical genetics
  • Animals and plants
  • Mutagenesis
  • Nuclear and chromosome architecture
  • Technology and methods

For more information on the the section aims and scope visit our sections information page.


Thomas Liehr, Institute of Human Genetics, Jena, Germany
Ivan Iourov, National Research Center of Mental Health, Moscow, Russia

Founding Editor

Yuri Yurov, National Research Center of Mental Health, Moscow, Russia


See here for a list of upcoming genetics meetings.

Relevant books

Chromothripsis: Methods and Protocols
Pellestor F (Editor; 2018)

Fluorescence in situ Hybridization (FISH) – Application Guide
Liehr T (Editor; 2017)

Uniparental Disomy (UPD) in Clinical Genetics
Liehr T (2014)

Human Interphase Chromosomes
Yurov YB, Vorsanova SG, Iourov IY (2013)

Small Supernumerary Marker Chromosomes (sSMC)
Liehr T (2012)

Fluorescence In Situ Hybridization (FISH) - Application Guide
Liehr T (2009)

FISH Technology
Rautenstrauss BW, Liehr T (2002)

About the European Cytogeneticists Association

The European Cytogeneticists Association (E.C.A.) was founded in 1997 and is registered in France.

The objectives of the Association are:

  • Representation and promotion of fundamental research and applications of cytogenetics
  • Organisation, assessment, and quality control of cytogenetic services in Europe
  • Research, education and training in all fields which are of interest to or concern cytogenetics and cytogeneticists
  • Facilitation of transfer of information and collaboration between laboratories.
  • Representation of professionals in cytogenetics
  • Study of questions and defence of interests concerning cytogeneticists or cytogenetics in general

Visit the E.C.A website to find out more.

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