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Nuclear and chromosome architecture

Section information

The impact of nuclear architecture is neither well studied nor well understood. Molecular cytogenetics is the best approach for studying the impact of chromosomal aberrations, as it is single cell-directed. This section publishes original research on the 3D structure of chromosomes and interphase nuclei.  Small movies can also be provided here as supplementary files to Molecular Cytogenetics.

  1. Content type: Research

    Childhood Acute Leukemia (AL) is characterized by recurrent genetic aberrations in 60% of AML cases and 90% of ALL cases. Insufficient data exists of rare cytogenetic abnormalities in AL. Therefore, we tested ...

    Authors: Nawaf Alkhayat, Ghaleb Elyamany, Yasser Elborai, Qanita Sedick, Mohammad Alshahrani, Omar Al Sharif, Abdulmalik Alenezy, Amjad Hammdan, Hatem Elghezal, Omar Alsuhaibani, Mansour S. Aljabry, May AlMoshary and Eman Al Mussaed

    Citation: Molecular Cytogenetics 2019 12:42

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  2. Content type: Research

    Pregnancy complications could lead to maternal and fetal morbidity and mortality. Early diagnosing and managing complications have been associated with good outcomes. The placenta was an important organ for de...

    Authors: Guangping Wu, Rong Li, Chao Tong, Miaonan He, Zhiwei Qi, Huijuan Chen, Tao Deng, Hailiang Liu and Hongbo Qi

    Citation: Molecular Cytogenetics 2019 12:38

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  3. Content type: Hypothesis

    Long telomeres, the protective caps of eukaryotic chromosomes, which erode during aging, have been the symbol of youth and regenerative potential. It therefore came as a surprise, when several cross-sectional ...

    Authors: Reinhard Stindl

    Citation: Molecular Cytogenetics 2019 12:37

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  4. Content type: Research

    Non-invasive prenatal testing (NIPT) has been widely used to detect common fetal chromosome aneuploidies, such as trisomy 13, 18, and 21 (T13, T18, and T21), and has expanded to sex chromosome aneuploidies (SC...

    Authors: Ying Xue, Guodong Zhao, Hong Li, Qin Zhang, Jiafeng Lu, Bin Yu and Ting Wang

    Citation: Molecular Cytogenetics 2019 12:29

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  5. Content type: Case Report

    Copy number variations (CNVs) involving the 17q12 region are associated with a broad range of clinical phenotypes. Deletion of the 17q12 chromosome results in structural or functional abnormalities in the kidn...

    Authors: Shanning Wan, Yunyun Zheng, Yinghui Dang, Tingting Song, Biliang Chen and Jianfang Zhang

    Citation: Molecular Cytogenetics 2019 12:19

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  6. Content type: Research

    We have previously described evidence for a statistically significant, global, supra-chromosomal representation of the human body that appears to stretch over the entire genome.

    Authors: Christopher Cherniak and Raul Rodriguez-Esteban

    Citation: Molecular Cytogenetics 2019 12:14

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  7. Content type: Case Report

    Copy number variations (CNVs) are largely known today, but their position is rarely established by fluorescence in situ hybridization (FISH) or karyotype analysis.

    Authors: Donatella Conconi, Nicoletta Villa, Serena Redaelli, Elena Sala, Francesca Crosti, Silva Maitz, Miriam Rigoldi, Rossella Parini, Leda Dalprà, Marialuisa Lavitrano and Gaia Roversi

    Citation: Molecular Cytogenetics 2018 11:52

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  8. Content type: Research

    Chromosomal abnormalities are one of the genetic mechanisms associated with abortion. However, the roles of submicroscopic chromosomal imbalances in early abortion are still unclear. This study aims to find ou...

    Authors: Haibo Li, Minjuan Liu, Min Xie, Qin Zhang, Jingjing Xiang, Chengying Duan, Yang Ding, Yinghua Liu, Jun Mao, Ting Wang and Hong Li

    Citation: Molecular Cytogenetics 2018 11:41

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  9. Content type: Hypothesis

    Chromosome counting is a process in which cells determine somehow their intrinsic chromosome number(s). The best-studied cellular mechanism that involves chromosome counting is ‘chromosome-kissing’ and X-chrom...

    Authors: Martina Rinčić, Ivan Y. Iourov and Thomas Liehr

    Citation: Molecular Cytogenetics 2016 9:56

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  10. Content type: Research

    One fundamental finding of the last decade is that, besides the primary DNA sequence information there are several epigenetic “information-layers” like DNA-and histone modifications, chromatin packaging and, l...

    Authors: Anja Weise, Samarth Bhatt, Katja Piaszinski, Nadezda Kosyakova, Xiaobo Fan, Annelore Altendorf-Hofmann, Alongklod Tanomtong, Arunrat Chaveerach, Marcelo Bello de Cioffi, Edivaldo de Oliveira, Joachim-U. Walther, Thomas Liehr and Jyoti P. Chaudhuri

    Citation: Molecular Cytogenetics 2016 9:36

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  11. Content type: Hypothesis

    Longer telomeres in the somatic cells of an individual have been regarded as a marker of youth and biological fitness within a population. Yet, several research groups have reported the surprising findings of ...

    Authors: Reinhard Stindl

    Citation: Molecular Cytogenetics 2016 9:12

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  12. Content type: Review

    Copy number variations (CNVs) having no (obvious) clinical effects were rediscovered as major part of human genome in 2004. However, for every cytogeneticist microscopically visible harmless CNVs (CG-CNVs) are...

    Authors: Thomas Liehr

    Citation: Molecular Cytogenetics 2016 9:5

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