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Nuclear and chromosome architecture

Section information

The impact of nuclear architecture is neither well studied nor well understood. Molecular cytogenetics is the best approach for studying the impact of chromosomal aberrations, as it is single cell-directed. This section publishes original research on the 3D structure of chromosomes and interphase nuclei.  Small movies can also be provided here as supplementary files to Molecular Cytogenetics.

  1. During mitosis, chromatin engages in a dynamic cycle of condensation and decondensation. Condensation into distinct units to ensure high fidelity segregation is followed by rapid and reproducible decondensatio...

    Authors: Seana L. Hill, Peter K. Rogan, Yi Xuan Wang and Joan H. M. Knoll
    Citation: Molecular Cytogenetics 2021 14:49
  2. The Genome Reference Consortium (GRC) has according to its own statement the “mission to improve the human reference genome assembly, correcting errors and adding sequence to ensure it provides the best repres...

    Authors: Thomas Liehr
    Citation: Molecular Cytogenetics 2021 14:20
  3. We presented two cases of mosaic trisomy 2 with high risk of maternal serum screening and non-invasive prenatal testing (NIPT). The invasive amniocentesis was performed and genetic tests including karyotype, s...

    Authors: Ting Wang, Jufei Lian, Congmian Ren, Huamei Huang, Yanlin Huang, Ling Xu, Laiping Zheng, Chanhui Cai and Li Guo
    Citation: Molecular Cytogenetics 2020 13:36
  4. Somatic chromosomal mosaicism is the presence of cell populations differing with respect to the chromosome complements (e.g. normal and abnormal) in an individual. Chromosomal mosaicism is associated with a wi...

    Authors: Svetlana G. Vorsanova, Yuri B. Yurov and Ivan Y. Iourov
    Citation: Molecular Cytogenetics 2020 13:16
  5. Chromosomal rearrangements in addition to t(15;17) have been reported in 25-40% of APL patients, with a large predominance of trisomy 8. Other abnormalities are far less frequent, particularly as ider(17), and...

    Authors: Yongming Liu, Junqing Xu, Lina Chu, Limei Yu, Yanhong Zhang, Li Ma, Weihua Wang, Yangyang Zhang, Yimin Xu and Riming Liu
    Citation: Molecular Cytogenetics 2020 13:13
  6. Childhood Acute Leukemia (AL) is characterized by recurrent genetic aberrations in 60% of AML cases and 90% of ALL cases. Insufficient data exists of rare cytogenetic abnormalities in AL. Therefore, we tested ...

    Authors: Nawaf Alkhayat, Ghaleb Elyamany, Yasser Elborai, Qanita Sedick, Mohammad Alshahrani, Omar Al Sharif, Abdulmalik Alenezy, Amjad Hammdan, Hatem Elghezal, Omar Alsuhaibani, Mansour S. Aljabry, May AlMoshary and Eman Al Mussaed
    Citation: Molecular Cytogenetics 2019 12:42
  7. Pregnancy complications could lead to maternal and fetal morbidity and mortality. Early diagnosing and managing complications have been associated with good outcomes. The placenta was an important organ for de...

    Authors: Guangping Wu, Rong Li, Chao Tong, Miaonan He, Zhiwei Qi, Huijuan Chen, Tao Deng, Hailiang Liu and Hongbo Qi
    Citation: Molecular Cytogenetics 2019 12:38
  8. Long telomeres, the protective caps of eukaryotic chromosomes, which erode during aging, have been the symbol of youth and regenerative potential. It therefore came as a surprise, when several cross-sectional ...

    Authors: Reinhard Stindl
    Citation: Molecular Cytogenetics 2019 12:37
  9. Non-invasive prenatal testing (NIPT) has been widely used to detect common fetal chromosome aneuploidies, such as trisomy 13, 18, and 21 (T13, T18, and T21), and has expanded to sex chromosome aneuploidies (SC...

    Authors: Ying Xue, Guodong Zhao, Hong Li, Qin Zhang, Jiafeng Lu, Bin Yu and Ting Wang
    Citation: Molecular Cytogenetics 2019 12:29
  10. Copy number variations (CNVs) involving the 17q12 region are associated with a broad range of clinical phenotypes. Deletion of the 17q12 chromosome results in structural or functional abnormalities in the kidn...

    Authors: Shanning Wan, Yunyun Zheng, Yinghui Dang, Tingting Song, Biliang Chen and Jianfang Zhang
    Citation: Molecular Cytogenetics 2019 12:19
  11. We have previously described evidence for a statistically significant, global, supra-chromosomal representation of the human body that appears to stretch over the entire genome.

    Authors: Christopher Cherniak and Raul Rodriguez-Esteban
    Citation: Molecular Cytogenetics 2019 12:14
  12. Copy number variations (CNVs) are largely known today, but their position is rarely established by fluorescence in situ hybridization (FISH) or karyotype analysis.

    Authors: Donatella Conconi, Nicoletta Villa, Serena Redaelli, Elena Sala, Francesca Crosti, Silva Maitz, Miriam Rigoldi, Rossella Parini, Leda Dalprà, Marialuisa Lavitrano and Gaia Roversi
    Citation: Molecular Cytogenetics 2018 11:52
  13. Chromosomal abnormalities are one of the genetic mechanisms associated with abortion. However, the roles of submicroscopic chromosomal imbalances in early abortion are still unclear. This study aims to find ou...

    Authors: Haibo Li, Minjuan Liu, Min Xie, Qin Zhang, Jingjing Xiang, Chengying Duan, Yang Ding, Yinghua Liu, Jun Mao, Ting Wang and Hong Li
    Citation: Molecular Cytogenetics 2018 11:41
  14. Chromosome counting is a process in which cells determine somehow their intrinsic chromosome number(s). The best-studied cellular mechanism that involves chromosome counting is ‘chromosome-kissing’ and X-chrom...

    Authors: Martina Rinčić, Ivan Y. Iourov and Thomas Liehr
    Citation: Molecular Cytogenetics 2016 9:56
  15. One fundamental finding of the last decade is that, besides the primary DNA sequence information there are several epigenetic “information-layers” like DNA-and histone modifications, chromatin packaging and, l...

    Authors: Anja Weise, Samarth Bhatt, Katja Piaszinski, Nadezda Kosyakova, Xiaobo Fan, Annelore Altendorf-Hofmann, Alongklod Tanomtong, Arunrat Chaveerach, Marcelo Bello de Cioffi, Edivaldo de Oliveira, Joachim-U. Walther, Thomas Liehr and Jyoti P. Chaudhuri
    Citation: Molecular Cytogenetics 2016 9:36
  16. Longer telomeres in the somatic cells of an individual have been regarded as a marker of youth and biological fitness within a population. Yet, several research groups have reported the surprising findings of ...

    Authors: Reinhard Stindl
    Citation: Molecular Cytogenetics 2016 9:12
  17. Copy number variations (CNVs) having no (obvious) clinical effects were rediscovered as major part of human genome in 2004. However, for every cytogeneticist microscopically visible harmless CNVs (CG-CNVs) are...

    Authors: Thomas Liehr
    Citation: Molecular Cytogenetics 2016 9:5