Identification of chromosomal abnormalities in miscarriages by CNV-Seq

Table 2 Statistics of cases with chromosomal abnormalities in various maternal age groups and gestational age groups

Characters	Maternal age (MA)						Gestational weeks (GW)
Characters	^AMA < 30 y	^B30 y ≤ MA < 35 y	^C35 y ≤ MA < 40 y	MA ≥ 40 y	χ2	P value	^DGW ≤ 12w	12 w < GW ≤ 28 w	χ²	P value
Numerical chromosomal abnormalities	90 (1)	89 (3)	41 (1)	23	25.379	< 0.05	228 (5)	15	7.466	< 0.05
Structural chromosomal abnormalities	65 (1)	47 (3)	7 (1)	0	11.722	< 0.05	101 (5)	18	6.348	< 0.05
pCNVs	18 (1)	11 (3)	2 (1)	0	0.285	0.867	28	3	0.480	0.488
VOUS	43	32	4	0	0.330	0.848	68	11	0.059	0.808

^AIn the group of MA < 30 y, 1 case was detected with both numerical and structural abnormalities, the structural abnormalities in this case detected were classified as pCNVs, this case was represented three times in this table. The number in the bracket represents the case mentioned, the same in below
^BIn the group of 30 ≤ MA < 35 y, 3 cases were detected with both numerical and structural abnormalities, the structural abnormalities detected in these cases were classified as pCNVs, these cases were represented three times in this table
^CIn the group of 35 ≤ MA < 40 y, 1 case was detected with both numerical and structural abnormalities, the structural abnormalities in this case detected were classified as pCNVs, this case was represented three times in this table
^DIn the group of GW ≤ 12 w, 5 cases were detected with both numerical and structural abnormalities

ISSN: 1755-8166