Table 1 Demographic, diagnostic data and karyotypes of Richter transformation patients

1^a

F/63; SLL; D(1)

Yes; LNc

No

DLBCL,

NOS (r)

42~46,XX,der(1)(1pter→?1q32::?1q32→?1q21::?1q32→?1q21:)[8],-2[3],add(3)(q21)[8],

-4[3],add(7)(q3?6)[4],-9[8],add(12)(p1?2)[7],+14 or +15 [6],-17[4],-18[4],-19[5],-21[5],+3~4mar[cp8]/46,XX[4]

2

F/62; SLL; D(3)

Yes; LNc

Yes, LNc

DLBCL,

NOS (r)

44~48,XX,-1,add(6)(q1?5),del(7)(q32),+del(7)(q32),-9,del(12)(q13),add(17)(p11),-21,der(?)t(?;1)(?;p13), der(?;?)(?→cen→?::?→cen→?::12q13→12qter),+3~4mar[cp14]

3^b

M/28; SLL; D(4)

Yes; LNc

Yes, LN

DLBCL,

NOS (r)

46,XY,del(2)(q23 or q31)[7]/47,sl,+3[2]/48,sdl1,+8[8]/46,XY[4]

4^a,b

M/67; SLL; D(3)

Yes; LNc

No

DLBCL,

NOS (r)

38~47,XY,add(1)(p3?4)[7],-9[12],der(9)del(9)(p2?)del(9)(q1?3)[12],add(9)(q?13)[20],del(11)(q?21q?23)[14],-17[5],+18[3],-21[8],+22[3],+der(?;?)(?→cen→?::?→cen→?::3q13→3qter)[24][cp26]

5

M/55; CLL; D(<1)

No; PB

No

B-LBL (u)

46~47,XY,add(14)(q32),+add(18)(q2?),+mar[cp7]/46,XY[4]

6

F/62; SLL; D(19)

Yes; LNc, PB

Yes, BM

DLBCL,

NOS (r)

53~59,<2n>,XX,+?del(1)(q2?1)[2],+3[9],+4[6],+5[10],+del(6)(q13)[8],+7 [8],+del(7)(q22)[2],+del(9)(q2?2)[2],+13[7],15[4],+16[8],+del(17)(p11)[6],+18[3],+19[8],+der(?19)t(1;?19)(p13;q21)[3],+20[11],+21[4],+21[6],+mar[cp12]

7^a

F/51; CLL; D(1)

No; PB

Yes, LI

DLBCL,

NOS (r)

45,XX,der(17)t(17;18)(p11.2;q11.2),-18[11]/45,idem,t(7;8)(p13;q24)[8]/46,XX[6]

8^a,b

F/63; CLL; nd

No; PB

No

DLBCL,

NOS (r)

nd

9

M/62, SLL D(6)

Yes; ST

Yes, ST

DLBCL,

NOS (u)

48,XY,add(8)(p?11.2),der(14)t(8;14)(q24;q32),+2mar[7]/48,idem,del(12)(p1?3)[3]

10

F/75; SLL; D(3)

Yes; LNc

No

DLBCL,

NOS (r)

42~44,X,-X,-17,+mar1,inc[cp2]

11

F/83; SLL; D(5)

Yes; LNinq

No

PBL (u)

45~47,-X[6],add(X)(p22)[4],-2[3],del(6)(q21)[6],?add(14)(q32)[3],-16[5],der(19)t(11;19)(q13;p13.3)[5],-22[4],+1~7mar[cp7]/46,XX[1]

12^a,b

M/62; SLL; D(7)

Yes; LNc, PB

No

DLBCL,

NOS (r)

71~86,XX,-Y,-1,add(3)(q2?7)x2,-4,-4,-5,-6,add(7)(q32)x3,-8,add(10)(q26)x2,add(11)(q23)x2,-12,-12,-13,-13,add(13)(q3?4)x2,-14,-14,add(14)(q32)x2,add(15)(p11)x2,-16,-17,+18,der(?)t(?;12) (?;q15)x2,+1~4mar[cp8]

13^b

M/81; SLL; D(1)

Yes; LNc

No

DLBCL,

NOS (r)

46,XY,-13,add(14)(q32),+mar[4]/46,XY[5]

14

F/67; SLL; nd

Yes; LNc, PB

Yes, LN, BM

DLBCL,

NOS (r)

44~47,XX,-1[8],-4[3],add(7)(q22)[4],-13[6],-14[8], +der(14)(?::14q32→14p11.2::?→ cen→?::14p11.2→14q32::?)[9],-15[5],-16[7],-18[5],add(19)(p13)[5],+der(?)t(1;?)(p13;?)[9], +4~7mar[cp9]/ 46,XY[3]

15^a

M/72; SLL; D(2)

Yes; LNab

No

DLBCL,

NOS (u)

47~50,XY,add(1)(q21)[10],+del(1)(p?31)[10],-2[6],del(3)(p12p14)[9], add(4)(q35)[10],-5[9],-7[10],-9[9],add(11)(q21)[7],-12[3],-13[7],-16[8],i(17)(q10)[10],-18[9],+20[10],+20[8], +21[5],+6-12mar[cp10]

16

F/70; SLL; D(11)

Yes, LNc, SofT

Yes, LN, SofT

DLBCL,

NOS (u)

44~44,XX,del(1)(p22p32),+del(1)(q3?2),add(8)(q24),-9,-11,add(13)(p13),-16,-17,-18, +7~11mar[cp4]

17^a,b

M/65; SLL; A(60)

Yes; LNc

No

HGBL-11q (u)

47,X,-Y,dup(11)(q22q23),+12,+mar1[4]/47,idem,add(18)(q23)[5]

18.^b

F/62; SLL; D(6)

Yes; LNc

No

DLBCL,

NOS (r)

46,XX,add(1)(q21),+del(1)(p22),-4,del(6)(q2?3),ins(7;?)(q22;?),-10,der(11)t(1;11)(q21;p15),del(13)(q?14q?22),add(19)(q13), +mar1[10]

19^a,b

F/50; CLL; D(2)

Yes; LNc, PB

Yes, BM

DLBCL,

NOS (r)

46~49,XX,del(1)(p13),+del(1)(q12),-2, add(7)(q36),+add(7)(q36),t(8;14)(q24;q32),-9, add(10)(p13),der(14)t(9;14)(q13;p11.2),del(15)(q2?4),i(17)(q10),add(19)(q13),-22, add(22)(q11),+1~2mar[cp20]

20^a

M/71; SLL; D(2)

Yes; LNc

Yes, LN

HS (u)

47,XY,+i(12)(q10),?t(15;22)(q15;q13)[9]/46,XY[2]

21^b

F/66; CLL; D(7)

Yes; LN, PB,

Yes, BM

DLBCL,

NOS (r)

49,X,-X,add(1)(p13),t(2;?20)(p11.2;p11.2),+3,+6,del(6)(q2?3), t(8;14)(q24;q32),+18,+mar1[10]

22

M/60; SLL; D(4)

Yes; LNc

Yes, LNc

DLBCL,

NOS (u)

45,XY,+X,del(1)(p32),-2,-7,del(11)(q21),-14,add(15)(p13),add(16)(q24),del(17)(p11),+mar1[7]/46,XY[1]

23^a,b

M/42; CLL; D(2)

No; PB, BM

Yes, BM

DLBCL,

NOS (r)

42~43,X,-Y,der(1)add(1)(p36)del(1)(q25)[5],-3[3],-4[5],add(4)(q3?5)[5],-5[3],add(7)(q36)[4],-8[5],-9[3],-10[4],-12[5],-13[5],add(15)(q15)[5], +mar1[3],+mar2[5],+mar3[4][cp5]/ 43~45,XY,add(1)(q4?4)[4],-4[4],add(4)(q3?5)[4],add(7)(q36)[4],-8[4],-9[4],-10[3],-12[4],-13[4], add(15)(q15)[4],+mar1[4],+mar2[2],+3mar[3][cp4]/ 45,XY[1]

24.

F/68; CLL; D(8)

No; BM

Yes, BM

DLBCL,

NOS (r)

54,X,der(X)t(X;1)(p22;p13),-1,del(4)(q2?6),add(8)(p?11.2),+9,del(10)(p12),+11,+13,+13, del(13)(q2?1q2?2),+14,+19,-20,+21,+der(?)t(?;1)(?;q21),+mar1,+mar2[8]/46,XX[3]

25

F/61; CLL; D(<1)

Yes; LNc, PB

No

DLBCL,

NOS (r)

46,XX,add(1)(p36),-5,ins(7;?)(q22;?),-8,del(9)(q?21q?22),-16,del(17)(p11.2),add(19)(q13),+mar1,+mar2,+mar3[10]

26^a

M/63; CLL; A(68)

Yes; LNc,

Yes, LN

DLBCL,

NOS (u)

46~50,XY,+X[3],add(1)(p36)[6],-4[5],+7[5],+10[4],+11[6],t(14;18)(q32;q21)[5],add(15)(q26)[5],+mar1[5],+mar2[3],+1~4mar[4][cp6]/46,XY,add(6)(q2?7)[2]/46,XY[2]

27

M/81; SLL; D(1)

Yes; LNc,

No

DLBCL,

NOS (r)

46,XY,-13,add(14)(q32),+mar[4]/46,XY[5]

28^a

M/53; SLL; D(4)

Yes; jaw tumor, PF

Yes, oral gingiva

DLBCL,

NOS (u)

44~47,XX,del(1)(p2?2)[2],del(1)(q12)[2],+7[3],del(8)(q24)[2],add(14)(q32)[3],-17[3],+der(?)t(?;1)(?;q21)[3][cp4]/46,XX[1]

29

F/94; CLL; A(5)

Yes; LNax, PB

No

DLBCL,

NOS (u)

46,XX,del(1)(p13),der(1)add(1)(p3?6)?add(1)(q25),+del(3)(q2?5),del(6)(q21),i(6)(p10),add(9)(p13),del(13)(q22),-14,-15,+18,add(19)(p13),-21,-22,+mar1,+mar2[10]

30^a

M/71; SLL; D(2)

Yes; LNab

No

HGBL,

NOS (u)

47~50,XY,add(1)(q21)[10],+del(1)(p?31)[10],-2[6],del(3)(p12p14)[9],add(4)(q35)[10],-5[9],-7[10],-9[9],add(11)(q21)[7],-12[3],-13[7],-16[8],i(17)(q10)[10],-18[9],+20[10],+20[8],+21[5],+6~12mar[cp10]

31

M/78; SLL; D(<1)

Yes; LNil

No

DLBCL,

NOS (r)

nd

32

M/87; CLL; nd

No; PB

No

DLBCL,

NOS (r)

47,XY,+5,del(2)(p11.2),der(8)t(2;8)(p11.2;q24),del(11)(q21),der(14)t(8;14)(q24;q32)[15]

33

M/66; CLL; D(9)

Yes; LNax

Yes, LN

DLBCL,

NOS (r)

85~93,XXYY,+mar[4][cp6]/46,XY[2]