Fig. 1

Cytogenomic data of case 17 with Richter transformation presented as high-grade B-cell lymphoma with 11q aberrations. A Karyotypes of RT and CLL paired phases, which demonstrate evolution of cytogenetic aberrations at RT transformation: CLL karyotype 46,XY[20], RT karyotype 47,X,-Y,dup(11)(q22q23), + 12, + mar1[4]/47,idem,add(18)(q23)[5] {red arrow indicates dup(11q)}. B FISH on RT metaphases (11 centromere signals are blue, red arrows indicate dup(11q) with 11q-gain/loss): a few KMT2A (yellow) signals on dup(11q) and one KMT2A signal on normal chromosome 11, 11qtel (red) signal on normal chromosome 11 and lack of 11qtel signal on dup(11q). C CGH/SNP array result: ideogram of chromosome 11, below copy number (CN) variations indicating duplication and deletion of 11q, underneath big brown blocks demonstrating loss of heterozygosity. Lower section shows magnification of aCGH analysis (CN variations). Green dots indicate gain, red dots shows deletion regions