Characteristic | SP group | IVF group | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Singleton | Twin | Singleton | Twin | |||||||||||||
NIPT result | T21 | T18 | T13 | SCA | T21 | T18 | T13 | SCA | T21 | T18 | T13 | SCA | T21 | T18 | T13 | SCA |
High-risk result (n) | 276 | 76 | 33 | 410 | 2 | 1 | 0 | 6 | 7 | 2 | 1 | 12 | 1 | 0 | 0 | 4 |
Diagnostic results (n) | 239 | 54 | 23 | 240 | 0 | 1 | 0 | 1 | 6 | 1 | 0 | 8 | 1 | 0 | 0 | 2 |
TP (n) | 213 | 28 | 5 | 96 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 4 | 1 | 0 | 0 | 0 |
FP (n) | 26 | 26 | 18 | 144 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 4 | 0 | 0 | 0 | 2 |
TN (n) | 89,090 | 89,276 | 89,307 | – | 1205 | 1204 | 1205 | – | 2880 | 2885 | 2886 | – | 559 | 560 | 560 | – |
FN (n) | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sensitivity (%) | 99.53 | 100.00 | 100.00 | – | – | – | – | – | 100.00 | – | – | – | 100.00 | – | – | – |
Specificity (%) | 99.97 | 99.97 | 99.98 | – | 100.00 | 99.92 | 100.00 | – | 99.93 | 99.97 | 100.00 | – | 100.00 | 100.00 | 100.00 | – |
PPV (%) | 89.12 | 51.85 | 21.74 | 40.00 | – | 0.00 | – | 100.00 | 66.67 | 0.00 | – | 50.00 | 100.00 | – | – | 0.00 |
NPV (%) | 99.99 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 |