Table 7 Comparison of findings with reports from North Africa & South Asia
From: Cytogenetic profile of 1791 adult acute myeloid leukemia in India
Country | India | Tunisia | Morocco | Egypt | Pakistan | India | India |
|---|---|---|---|---|---|---|---|
Reference | This study | Gmidene | Khoubila | El-Naggar | Shaikh | Amare | Namratha |
Year | 2023 | 2012 | 2019 | 2021 | 2018 | 2016 | 2020 |
Duration of study | 2003–17 | 2000–07 | 2004–14 | 2019–21 | 2011–16 | 2008–15 | 2013–14 |
Type of study | Hosp-based | Hosp based | Hosp-based | Hosp-based | Hosp-based | Hosp-based | Hosp-based |
No. of cases | 1791 | 631 | 927 | 120 | 321 | 2042 | 203 |
Karyotypes analysed | 1791 | 631 | 895 | 120 | 288 | 1906 | 173 |
Age, median (range) | 42 (18–85) | 37 (8 dy–95y) | 40.5 (20–60) | 36.5 (18–86) | NA, ≥ 15 | 38 (16 -86) | 39 (16–82) |
Male:Female ratio | 1.5:1 | 1.3:1 | 1.1:1 | 1.1:1 | 1.7:1 | 1.5:1 | 1.1:1 |
Normal karyotypes | 36.1 | 37.1 | 42 | 56.7 | 61.1 | NA | 34.6 |
Abnormal karyotypes | 63.9 | 62.9 | 58 | 43.3 | 38.9 | NA | 65.4 |
inv(3)/t(3;3) | 1.8 | NA | 0.6 | 1.6 | NA | 1.5 | 3.4 all 3q |
Del (5q)/minus 5 | 3.6/3.1 | NA | 0.5 | nil | NA | 3.4 | 2.3 del 5 |
t (6;9) | 0.9 | NA | NA | NA | 0.7 | NA | 1.1 |
Minus 7/del (7q) | 6.8/2.5 | 3 | 2.9/- | 0.8 | 1 | 6.3 | 1.1 del 7 |
Plus 8 | 11.6 | 7 | 4.5 | 3.3 | 2.4 | 8.4 | NA |
t(8;21) | 7.2 | 12.2 | 12.5 | 7.5 | 8.3 | 14.7 | 20.8 |
t(9;22) | 1.1 | NA | NA | 0.8 | NA | NA | NA |
t(9;11) | 0.8 | NA | 1 | NA | NA | 2 | 3.4 |
Other/all^11q23 | 1.6 | 3.8^ | 2.6 | 7.5^ | NA | 3 | NA |
t(15;17) | 16.7 | 13.2 | 3.7 | 9.2 | 4.9 | 9.4 | 8.6 |
inv(16)Â /t(16;16) | 1.7 | 3.5 | 3.3 | 7.5 | 0.7 | 4.5 | 21.3^^ |
Minus 17/abn 17p | 3.5/1.7 | NA | NA | 0.8 iso 17q | NA | 2 | 0.5 |
Plus 21 | 4.6 | NA | NA | NA | NA | NA | NA |
Complex (≥ 3)/CK** | 15.6/11.2** | 10.8 | 7.4 | 0.8 | 9 | NA | 2.3 |