Table 5 Comparison of findings with Western literature
From: Cytogenetic profile of 1791 adult acute myeloid leukemia in India
Country | India | Germany | USA | UK | UK | Spain | Sweden | Germany | Australia | Australia |
|---|---|---|---|---|---|---|---|---|---|---|
Reference | This study | Bacher | Byrd | Sanderson | Grimwade | Sierra | Lazarevic | Creutzig | Nakase | Gangatharan |
Year | 2023 | 2005 | 2002 | 2006 | 2010 | 2006 | 2014 | 2016 | 2000 | 2021 |
Duration of study | 2003–17 | 1996–04 | 1984–95 | 1983;98–06 | 1988–09 | 1995–02 | 1997–06 | 1998;05–12 | 1986–97 | 2009–18 |
Type of study | Hosp | Hosp | CALGB | Pop | MRC | Hosp | Pop | Hosp | Hosp | Hosp |
No. of cases | 1791 | 2460 | 1311 | 1709 | 5876 | 1271 | 3251 | 4516 | 368 | 734 |
Karyotypes analysed | 1791 | 2235 | 1213 | 1192 | 5876 | 1129 | 1893 | 4372 | 230 | 710 |
Age, median (range) | 42 (18–85) | NA (16–90) | 52 (15–86) | 62 (16–99) | 44 (16–59) | 61 (1–94) | 66 (18- > 80) | 0–100 | 51* (16–86) | 64 (16–94) |
Male:Female ratio | 1.5:1 | NA | 1:1 | 1.1:1 | NA | 1.2:1 | NA | NA | 1.3:1 | 1.3:1 |
Normal | 36.1 | 58 | 48 | 45 | 41 | 36 | 43 | 49 | 44 | 39 |
Abnormal | 63.9 | 42 | 52 | 55 | 59 | 64 | 57 | 51 | 56 | 61 |
inv(3)/t(3;3) | 1.8 | 1.6 | 1.0 | NA | 1 | 3.2` 3q | 1 | 1.3 | NA | 0.7 |
Del (5q)/minus 5 | 3.6/3.1 | 1.7 | 3.5/2.1 | 5/2 | 2,2 | 9.1 | 13 | 1.5 | 13.5*** | 0.5 |
t (6;9) | 0.9 | NA | 0.7 | NA | 1 | NA | 0.2 | 0.3 | NA | NA |
Minus 7/del (7q) | 6.8/2.5 | 2.6 | 3.9/1.6 | 3/2 | 5,2 | 8.6 | 13 | 1.8 | 13.5*** | 3.5 |
Plus 8 | 11.6 | 5.7 | 10.1 | 6 | 10 | 11.4 | 4.3 | 5.6 | 13.5*** | 5.7 |
t(8;21) | 7.2 | 4.3 | 6.7 | 4 | 7 | 2.7 | 1.9 | 2.6 | 5.2 | 3.1 |
t(9;22) | 1.1 | NA | NA | 1 | 1 | NA | NA | NA | NA | 0.1 |
t(9;11) | 0.8 | NA | 2.2 | 1 | 1 | NA | 0.7 | 0.8 | NA | NA |
Other/all^11q23 | 1.6 | 2.7^ | 2.3 | 1 | 3 | 3.3^ | 1.1 | 1.5 | 2.6^ | 3.5^ |
t(15;17) | 16.7 | NA | NA | 8 | 13 | 14.8 | NA | 5.2 | 11.7 | 7.8 |
inv(16)/t(16;16) | 1.7 | NA | 7.9 | 2 | 5 | 2.7 | 2.2 | 2.5 | 6.1 | 1.9 |
Minus 17/abn 17p | 3.5/1.7 | 0.2 (i 17q) | 5.1 | NA | 2,2 | NA | 8.8 | 0.4 | NA | NA |
Plus 21 | 4.6 | 0.8 | 2.3 | NA | 3 | NA | NA | NA | NA | 0.7 |
Complex( ≥ 3)/CK** | 15.6/11.2** | 12.3 | 11.1 | 15 |  < 14** | 19 | 24 | 14.5 | NA | 20.6 |