Table 4 Abnormalities other than RGA and MRC (n =  ≥ 20)
From: Cytogenetic profile of 1791 adult acute myeloid leukemia in India
Abnormality | Patient characteristics, n (%) | Age distribution, years, n (%) | Karyotype complexity, n (%) | Assoc with RGA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | Total | M | F | Age | p | 18–20 | 21–39 | 40–59 |  ≥ 60 | Single | Two |  ≥ 3 | Double |  ≥ 3 |
Minus 5 | 55 (3.1) | 37 (67.2) | 18 (32.8) | 54 (21–78) | Ref* | 0 | 12 (21.8) | 25 (45.5) | 18 (32.7) | 0 | 0 | 55 (100) | 0 | 2 (5.5) |
Plus 4 | 54 (3) | 35 (64.8) | 19 (35.2) | 38 (18–73) | 0.001 | 5 (9.3) | 23 (42.6) | 18 (33.3) | 8 (14.8) | 10 (18.5) | 14 (25.9) | 30 (55.6) | 4 (7.4) | 4 (7.4) |
Plus 6 | 33 (1.8) | 22 (66.7) | 11 (33.3) | 43 (18–65) | 0.009 | 2 (6.1) | 13 (39.4) | 14 (42.4) | 4 (12.1) | 2 (6.1) | 1 (3) | 30 (90.9) | 0 (0) | 2 (6.1) |
del 6q | 20 (1.1) | 15 (75) | 5 (25) | 40.5 (18–78) | 0.02 | 1 (5) | 9 (45) | 7 (35) | 3 (15) | 0 | 2 (10) | 18 (90) | 1 (5) | 1 (5) |
Plus 9 | 28 (1.6) | 17 (60.7) | 11 (39.3) | 39 (18–73) | 0.01 | 2 (7.1) | 13 (46.4) | 8 (28.6) | 5 (17.9) | 4 (14.3) | 3 (10.7) | 21 (75) | 0 (0) | 1 (3.6) |
Minus 9 | 26 (1.5) | 18 (69.2) | 8 (30.8) | 36 (21–78) | 0.07 | 0 (0) | 14 (53.8) | 6 (23.1) | 6 (23.1) | 0 (0) | 2 (7.7) | 24 (92.3) | 0 (0) | 2 (7.7) |
del 9q | 60 (3.4) | 36 (60) | 24 (40) | 37 (18–78) |  < 0.001 | 4 (6.7) | 28 (46.7) | 20 (33.3) | 8 (13.3) | 14 (23.3) | 12 (20) | 34 (56.7) | 9 (15) | 15 (25) |
Plus 10 | 26 (1.5) | 17 (65.4) | 9 (34.6) | 45.5 (20–78) | 0.06 | 1 (3.8) | 10 (38.5) | 8 (30.8) | 7 (26.9) | 1 (3.8) | 2 (7.7) | 23 (88.5) | 0 (0) | 2 (7.7) |
Minus 10 | 20 (1.1) | 13 (65) | 7 (35) | 46 (21–75) | 0.05 | 0 (0) | 7 (35) | 10 (50) | 3 (15) | 0 (0) | 1 (5) | 19 (95) | 0 (0) | 2 (10) |
Plus 11 | 36 (2) | 23 (63.9) | 13 (36.1) | 53 (19–78) | 0.21 | 2 (5.6) | 9 (25) | 17 (47.2) | 8 (22.2) | 9 (25) | 6 (16.7) | 21 (58.3) | 1 (2.8) | 1 (2.8) |
Minus 11 | 22 (1.2) | 12 (54.5) | 10 (45.5) | 50.5 (20–78) | 0.24 | 1 (4.5) | 7 (31.8) | 7 (31.8) | 7 (31.8) | 0 (0) | 0 (0) | 22 (100) | 0 (0) | 2 (9.1) |
Minus 12 | 34 (1.9) | 24 (70.6) | 10 (29.4) | 53 (21–77) | 0.21 | 0 (0) | 9 (26.5) | 18 (52.9) | 7 (20.6) | 0 (0) | 0 (0) | 34 (100) | 0 (0) | 3 (8.8) |
Plus 13 | 41 (2.3) | 28 (68.3) | 13 (31.7) | 53 (18–75) | 0.14 | 2 (4.9) | 11 (26.8) | 18 (43.9) | 10 (24.4) | 5 (12.2) | 4 (9.8) | 32 (78) | 0 (0) | 4 (9.8) |
Plus 14 | 27 (1.5) | 18 (66.7) | 9 (33.3) | 43 (18–73) | 0.05 | 1 (3.7) | 10 (37) | 11 (40.7) | 5 (18.5) | 0 (0) | 2 (7.4) | 25 (92.6) | 1 (3.7) | 1 (3.7) |
Minus 14 | 20 (1.1) | 16 (80) | 4 (20) | 39 (24–59) | 0.09 | 0 (0) | 5 (25) | 12 (60) | 3 (15) | 0 (0) | 0 (0) | 20 (100) | 0 (0) | 3 (15) |
Minus 16 | 38 (2.1) | 25 (65.8) | 13 (34.2) | 53 (20–82) | 0.44 | 1 (2.6) | 14 (36.8) | 9 (23.7) | 14 (36.8) | 0 (0) | 0 (0) | 38 (100) | 0 (0) | 1 (2.6) |
Minus 18 | 48 (2.7) | 34 (70.8) | 14 (29.2) | 49.5 (18–78) | 0.09 | 1 (2.1) | 15 (31.3) | 18 (37.5) | 14 (29.2) | 0 (0) | 3 (6.3) | 45 (93.8) | 1 (2.1) | 3 (6.3) |
Plus 19 | 45 (2.5) | 34 (75.6) | 11 (24.4) | 40 (18–73) | 0.004 | 2 (4.4) | 20 (44.4) | 14 (31.1) | 9 (20) | 5 (11.1) | 2 (4.4) | 38 (84.4) | 1 (2.2) | 8 (17.8) |
Minus 20 | 24 (1.3) | 18 (75) | 6 (25) | 53 (19–78) | 0.77 | 1 (4.2) | 7 (29.2) | 9 (37.5) | 7 (29.2) | 0 (0) | 2 (8.3) | 22 (91.7) | 0 (0) | 2 (8.3) |
Plus 21 | 83 (4.6) | 46 (55.4) | 37 (44.6) | 40 (18–73) |  < 0.001 | 4 (4.8) | 37 (44.6) | 30 (36.1) | 12 (14.5) | 16 (19.3) | 10 (12) | 57 (68.7) | 1 (1.2) | 14 (16.9) |
Minus 21 | 24 (1.3) | 16 (66.7) | 8 (33.3) | 48.5 (21–78) | 0.1 | 0 (0) | 11 (45.8) | 7 (29.2) | 7 (29.2) | 0 (0) | 0 (0) | 24 (100) | 0 (0) | 0 (0) |
Plus 22 | 43 (2.4) | 30 (69.8) | 13 (30.2) | 43 (18–78) | 0.003 | 2 (4.7) | 18 (41.9) | 16 (37.2) | 7 (16.3) | 1 (2.3) | 7 (16.3) | 35 (81.4) | 3 (7) | 6 (14) |
Minus 22 | 22 (1.2) | 14 (63.6) | 8 (36.4) | 53 (20–78) | 0.28 | 1 (4.5) | 6 (27.3) | 9 (40.9) | 6 (27.3) | 0 (0) | 0 (0) | 22 (100) | 0 (0) | 2 (9.1) |
Minus X | 37 (2.1) | 7 (18.9) | 30 (81.1) | 37 (18–70) |  < 0.001 | 4 (10.8) | 18 (48.6) | 12 (32.4) | 3 (8.1) | 0 (0) | 16 (43.2) | 21 (56.8) | 14 (37.8) | 9 (24.3) |
Minus Y | 81 (4.5) | 0 (0) | 81 (100) | 36 (18–74) |  < 0.001 | 7 (8.6) | 39 (48.1) | 25 (30.9) | 10 (12.3) | 10 (12.3) | 47 (58) | 24 (29.6) | 47 (58) | 10 (12.3) |