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Table 2 Recurrent genetic abnormalities in AML

From: Cytogenetic profile of 1791 adult acute myeloid leukemia in India

Abnormality

t(15;17)

t(8;21)#

inv(16)*

t(9;11)

inv(3)/t (3;3)^

t(6;9)

t(9;22)

Other t (v;11q23)##

t NUP98**

Rare t^^

Patients, n (%)

          

All

299 (16.7)

129 (7.2)

31 (1.7)

14 (0.8)

32 (1.8)

16 (0.9)

19 (1.1)

28 (1.6)

8 (0.4)

10 (0.6)

M

162 (54.2)

77 (59.7)

13 (41.9)

9 (64.3)

23 (71.9)

12 (75)

11 (57.9)

14 (50)

3 (37.5)

4 (40)

F

137 (45.8)

52 (40.3)

18 (58.1)

5 (35.7)

9 (28.1)

4 (25)

8 (42.1)

14 (50)

5 (62.5)

6 (60)

Age

35 (18–75)

33 (18–76)

36 (20–71)

33 (18–58)

41 (24–73)

40.5 (21–65)

39 (23–57)

40.5 (18–65)

43 (22–67)

31 (20–54)

P value for age

Reference

0.04

0.53

0.52

0.02

0.06

0.26

0.22

0.14

0.12

Karyotype complexity

          

Single abn

210 (70.2)

20 (15.5)

20 (64.5)

6 (42.9)

11 (34.4)

13 (81.3)

7 (36.8)

19 (67.9)

6 (75)

4 (40)

Two abn

60 (20.1)

88 (68.2)

5 (16.1)

5 (35.7)

13 (40.6)

3 (18.8)

7 (36.8)

6 (21.4)

1 (12.5)

3 (30)

 ≥ 3 abn

29 (9.7)

21 (16.3)

6 (19.4)

3 (21.4)

8 (25)

0

5 (26.3)

3 (10.7)

1 (12.5)

3 (30)

Additional cytogenetic abnormalities

          

del 5q

1

1

–

–

4

–

–

1 t(11;19) q13.3)

–

–

Minus 7

–

3

–

1

15

–

3

–

–

–

del 7q

4

2

1

–

–

–

1

–

–

–

Plus 8

28

4

7

5

1

–

2

4 t(6;11)

1 t(7;11)

1 t (10;11)

del 11q

1v

–

–

–

–

–

–

–

–

–

Del/other 12p

–,1

–

–

–

–

–

–

–

–

1 t (10;11),–

Minus 13/del 13q

1,–

1,–

–

–

–/1

–

1,–

–

–

–

Minus 17

2

1

–

–

1

–

1

–

–

–

Iso/ider 17q***

2,7

–

–

–

–

–

–

–

1 t(7;11),–

–

Del/other 17p

–,1

–,1

–

–

–

–,1

–

–

–

–

Plus 4

2

5

–

–

1

–

–

–

–

–

Minus 5

–

1

–

–

1

–

–

–

–

–

del 9q

6

16

1

–

–

–

–

1

–

–

Minus 18

1

1

–

–

2

–

–

–

–

–

Plus 19

1

1

–

3

–

–

1

2 t(6;11)

1 t(7;11)

–

Plus 21

9

–

2

1

–

–

1

2 t(6;11)

–

–

Plus 22

1

–

6

1

1

–

–

–

–

–

Minus X

–

20

–

–

1

–

–

–

–

2 t(10;11),

Minus Y

–

54

–

–

–

1

–

–

–

1 t(16;21)

  1. t, translocation; t(15;17)(q24;q21); #t(8;21)(q22;q22) includes one with concurrent t(3;3); inv, inversion; *inv(16)(p13.1q22),n =30 and t (16;16)(p13.1;q22),n =1; t(9;11)(p13;q23); ^inv(3)(q21q26), n =17/t(3;3)(q21;q26),n =15; t(6;9)(p22;q34); t(9;22)(q34;q11.2); ## Other t(v;11q23): t(6;11)(q27;q23.3),n =9; t (10;11)(p12.3;q23.3),n =5; t(10;11)(q21.3;q23.3),n =1; t(11;19)(q23.3;p13.1), n =4; t(11;19)(q23.3;p13.3),n =3; t(11;17)(q23;q25),n =3; t(X;11) (q22;q23),n =2; t(1;11)(q21;q23),n =1;**NUP98 translocations: t(7;11) (p15;p15),n =4; t(11;20)(p15;q12),n = 2; t(2;11)(q31;p15),n =1; t(11;12)(p15;p13),n = 1; ^^rare translocations: t(10;11)(p11;q14), n = 6; t (1;3)(p36;q21),t(3;5)(q25;q35),t(8;16)(p11;p13) & t(16;21)(p11.2;q22),n = 1 each; abn,abnormality; del,deletion; ***,iso/ider17q, isochromosome 17q and isoderivative 17q.
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Molecular Cytogenetics

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