Fig. 6
From: Mechanisms of structural chromosomal rearrangement formation
Chromoanagenesis. A Chromothripsis: (a) A missegregated chromosome is encapsulated inside a micronucleus and suffers multiple double-strand breaks, leading to (b) the shattering of the chromosome. (c) The chromosome is reassembled by c-NHEJ or MMEJ and reincorporated in the nucleus. Deletions due to loss of DNA fragments can occur. B Chromoanasynthesis: (a) A chromosome undergoes (b) DNA segment re-synthesis in a process that involves FoSTeS or MMBIR, forming (c) a new chromosome, which can present inversions, deletions, duplications, and triplications. C Chromoplexy: (a) Different chromosomes suffer (b) double-strand breaks and, after recombination by NHEJ or MMEJ, (c) form chromosomes with translocations. Based on (59)