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Table 2 Characteristics of five reported DI-MDS cases and the presented two cases

From: Myelodysplastic syndrome presenting with central diabetes insipidus is associated with monosomy 7, visible or hidden: report of two cases and literature review

Reference Age (years) MDS subtype Partial/complete deletion of chromosome 7 MRI abnormal Treatment of MDS Outcome of CDI Time to AML (months) OS (months)
Case 1 43 RAEB1 Yes A slightly thickened pituitary stalk and a small nodule in the left pituitary Allo-HCT Controlled by desmopressin and cured after HCT No 13 +
Case 2 40 RAEB1 Yes No Decitabine and Allo-HCT Controlled by desmopressin and HCT, reappeared when disease progress 2 11
4 74 RAEB 1 Yes No Supportive care Controlled by desmopressin 2 2
6 6 RAEB 1 Yes No Allo-HCT Controlled by desmopressin and cured after HCT No NA
7 53 RAEB 2 No (Norma karyotype) Nodular lesion on pituitary stalk & absent of posterior “bright spot” of neurohypophysis on T1-weighed MRI Chemotherapy and Allo-HCT Controlled by desmopressin and need for desmopressin persists after allo-HCT No 18 +
9 60 MDS-MLD No (Norma karyotype) Attenuation of “bright spot” Chemotherapy Recovered after chemotherapy 1 NA
10 73 NA Yes Absent of posterior “bright spot” & symmetrical enhancing lesions in the hypothalamus NA Temporary controlled by desmopressin 3 3
  1. MDS myelodysplastic syndrome, CDI central diabetes insipidus, MRI magnetic resonance imaging, NA not available, AML acute myeloid leukemia, OS overall survival, RAEB refractory anemia with excess blasts, Allo-HCT allogeneic hematopoietic cell transplant, MDS-MLD MDS with multilineage dysplasia