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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: Bi-allelic amplification of ATM gene in blastoid variant of mantle cell lymphoma: a novel mechanism of inactivation due to chromoanagenesis?

Fig. 1

a G-banded karyotype showing complex abnormalities from the bone marrow. Arrows point to the abnormal chromosomes. b Interphase FISH showing the 2F/1O/1G pattern for the CCND1 (orange) and IGH (green) probes indicating the CCND1/IGH fusion. Arrows point to the fusion signals. c Interphase FISH with RB1 probe at 13q14 (orange) and CTB-163C9 at 13q34 (green) probes showing 2O/1G pattern indicating distal 13q deletion. d Interphase FISH with IGH (green) and BCL2 (orange) probes showing 3O/3G pattern indicating gain of both IGH and BCL2 gene regions. e Interphase FISH with TP53 (orange) and D17Z1 (green) probes showing 1O/2G pattern indicating TP53 gene deletion. f Interphase FISH with ATM (orange) and D11Z1 (green) probe showing biallelic amplification of ATM gene region. Arrows point to the amplified ATM gene

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Molecular Cytogenetics

ISSN: 1755-8166