Table 3 Copy number alterations associated with molecular subtypes of human BC, according to [32], with the copy number variants (CNVs) in cell lines JC
From: Cytogenomic characteristics of murine breast cancer cell line JC
DNA changes | ||
|---|---|---|
In BC subtypes | Human BC | JC |
HER2+/ERBB2 | Â | Â |
17q11.1~12 | gain | no CNV |
17q21.31~23.2 | gain | gain but ERBB2 is not included |
SUM of concordance | 0/2 | |
Basal-like tumors | Â | Â |
 4p15.31 | loss | loss |
 5q12.3~13.2 | loss | gain |
 5q33.1 | loss | loss |
 6p12.3 | gain | no CNV |
 6p21.1~23 | gain | gain |
 8q24.21~24.22 | gain | gain |
 10p12.33~14 | gain | loss |
 10q23.33 | loss | loss |
 12q13.13 | loss | gain |
 12q13.3 | loss | loss |
 15q15.1 | loss | no CNV |
 15q21.1 | loss | no CNV |
SUM of concordance | 6/12 | |
Luminal A | Â | Â |
 1q21.3 | gain | no CNV |
 1q44 | gain | loss |
 16p13.13 | gain | no CNV |
 16p13.12 | gain | loss |
 16q11.2~13 | loss | no CNV |
 16q22.1-24.1 | loss | no CNV |
SUM of concordance | 0/6 | |
Luminal B | Â | Â |
 1p31.3 | loss | loss |
 8p21.2 | loss | loss |
 17q23.2 | gain | loss |
SUM of concordance | 2/3 | |