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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Coexistence of recurrent chromosomal abnormalities and the Philadelphia chromosome in acute and chronic myeloid leukemias: report of five cases and review of literature

Fig. 2

Bone marrow karyotype, metaphase-FISH, and fusion gene results of Case 2. a R-banded karyotype of case 2: 47,XX,t(5;7)(q31;q21),der(9)t(9;22)(q34;q11.2)t(9;11)(p22;q23),der(11)t(9;11)(p22;q23),+21,der(22)t(9;22)(q34;q11.2). Panels b-d represent FISH analysis on metaphase cells corresponding to karyotypes in panels a and b Metaphase FISH using dual color BCR-ABL1 fusion (ABL1: red; BCR: green). c Corresponding R-banded metaphase. d Sequential FISH using MLL-AF9 fusion (AF9: red; MLL: green) probe on the same metaphase cell, showing its MLL-AF9 fusion. e Metaphase FISH using dual color break apart probe showing PDGFRB(5q32-q33) with PDGFRB fusion (fusion red/green signal). f Corresponding R-banded metaphase. g BCR/ABL1 and MLL/AF9 results for patient 2. Red peak, BCR/ABL1; green peak, MLL/AF9; blue peak, internal reference ABL1

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Molecular Cytogenetics

ISSN: 1755-8166