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Table 2 Demographic data cases 6–9

From: Rare cytogenetic abnormalities and their clinical relevance in pediatric acute leukemia of Saudi Arabian population

Parameter Case 6 Case 7 Case 8 Case 9
Age (years) 14 18 5 4
Gender Male Male Male Male
Clinical Melena stools, fatigue Leucocytosis, anaemia, thrombocytopenia no organomegaly Generalized ecchymosis, bruises, epistaxis and hepatomegaly Fever, malaise failure to thrive
WBC (109/L) 16.5 33 16.1 100
HB (g/dl) 10.1 8.2 6.7 7.8
PLT (X109/L) 20 67 14 101
PB blasts 30% 70% 40% 70%
Bone marrow aspirate 90% blasts with AML MO morphology 70% blasts 40% blasts With dysplasia 90% blasts comprised of two distinct populations
Blasts 90% 70% 40% 90%
Cytogenetic analysis (karyotype/FISH) 46,XY,t(7;14) (q22;q32) 46,XY,t(11;20) (p15;q11), add(21)(p11) t(12;17)(q15;q23), del(7)(p15), inv. (8)(q22q24) with(2+) and(19+) 46,XY,der(15)t(1;15) (q10;q10),der(17) t(17;19)(q21;p13.3)
Chemotherapy Received induction (3 + 7) for AML then high risk MAC/G protocol AML induction chemotherapy (3 + 7) protocol. Allogeneic stem cell transplant with steroid refractory graft vs host disease treated with ATG MRC AML12 Protocol Received 7 chemotherapy cycles
Survival Refractory disease and demised secondary to chemotherapy side effects Complete remission Patient demised Not attain remission Status. Relapsed for MUD transplant