Table 3 NIPT results for common fetal chromosome aneuploidies and SCAs on two NGS platforms
From: Non-invasive prenatal testing to detect chromosome aneuploidies in 57,204 pregnancies
Chromosome aneuploidies | Illumina | Proton | p-value (Illumina vs Proton) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
ST (%) | SP (%) | PPV (%) | ST (%) | SP (%) | PPV (%) | ST | SP | PPV | ||
21 | 98.34 | 99.94 | 88.94 | 98.84 | 99.91 | 82.52 | 0.756 | 0.169 | 0.119 | |
18 | 98.00 | 99.96 | 77.78 | 100.00 | 99.94 | 60.71 | 0.561 | 0.326 | 0.092 | |
13 | 100.00 | 99.97 | 25.00 | 100.00 | 99.91 | 18.18 | 1.000 | 0.004 | 0.611 | |
SCAs | 45, X | 100.00 | 99.79 | 19.39 | 100.00 | 99.95 | 28.57 | 1.000 | < 0.001 | 0.426 |
47, XXX | 100.00 | 99.98 | 55.56 | 100.00 | 99.99 | 80.00 | 1.000 | 0.330 | 0.196 | |
47, XXY | 100.00 | 99.97 | 55.17 | 100.00 | 99.99 | 92.31 | 1.000 | 0.031 | 0.018 | |
47, XYY | 100.00 | 100.00 | 85.71 | 100.00 | 99.99 | 66.67 | 1.000 | 0.244 | 0.416 | |