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Table 3 NIPT results for common fetal chromosome aneuploidies and SCAs on two NGS platforms

From: Non-invasive prenatal testing to detect chromosome aneuploidies in 57,204 pregnancies

Chromosome aneuploidies Illumina Proton p-value (Illumina vs Proton)
ST (%) SP (%) PPV (%) ST (%) SP (%) PPV (%) ST SP PPV
21 98.34 99.94 88.94 98.84 99.91 82.52 0.756 0.169 0.119
18 98.00 99.96 77.78 100.00 99.94 60.71 0.561 0.326 0.092
13 100.00 99.97 25.00 100.00 99.91 18.18 1.000 0.004 0.611
SCAs 45, X 100.00 99.79 19.39 100.00 99.95 28.57 1.000 < 0.001 0.426
47, XXX 100.00 99.98 55.56 100.00 99.99 80.00 1.000 0.330 0.196
47, XXY 100.00 99.97 55.17 100.00 99.99 92.31 1.000 0.031 0.018
47, XYY 100.00 100.00 85.71 100.00 99.99 66.67 1.000 0.244 0.416
  1. NGS next-generation sequencing, PPV positive predictive value, SCA sex chromosome aneuploidies, SP specificity, ST sensitivity