Table 2 Chromosomal location, occurrence of breakpoint events (BP), odds ratio, located genes and association to fragile sites of the top-ranked CCLE breakpoint regions. Genes that are associated with cancer in literature are marked with an asterisk. Interestingly, the breakpoint region in chromosome 2 is close to the cancer associated SDC1 gene by about 558 bases
From: Genome reorganization in different cancer types: detection of cancer specific breakpoint regions
Chr | Start | End | Cytoband | BP in NMCE (20) | BP in Tumors (111) | Odds Ratio | BP in CCLE (917) | Gene | Fragile Sites |
|---|---|---|---|---|---|---|---|---|---|
2 | 20300001 | 20400001 | 2p24.1 | 0 | 9 | 3,73 | 248 | – | – |
4 | 190900001 | 191000001 | 4q35.2 | 0 | 14 | 5,98 | 190 | FRG2 | FRA4L, FRA4M |
7 | 159100001 | 159119220 | 7q36.3 | 0 | 22 | 10,11 | 230 | – | FRA7I |
8 | 146200001 | 146300001 | 8q24.3 | 0 | 21 | 9,56 | 238 | C8orf33* | FRA8D |
9 | 141000001 | 141100001 | 9q34.3 | 1 | 48 | 14,48 | 321 | CACNA1B* | FRA9N |
13 | 115100001 | 115106996 | 13q34 | 3 | 40 | 3,19 | 210 | – | FRA13I |
16 | 85000001 | 85100001 | 16q24.1 | 0 | 8 | 3,30 | 244 | KIAA0513*, ZDHHC7 | FRA16J |