Fig. 2

Whole genome snapshot of varying levels of aneuploidy in the different PTEN deletion subtypes. The genome is displayed horizontally, and the frequency of SCNAs at any given location are displayed on the y-axis. Red and blue indicate losses and gains, respectively. The black vertical continuous lines identify the chromosomal regions common to all subtypes that have marked differential copy numbers in comparison to PTEN intact. Chromosomes 3, 8, 13, and 21 were the most affected regions common to all subtypes. The red and blue dashed boxes identify regions that presented a high frequency of deletions and gains, respectively. Box A identifies the three deletion subtypes with a high frequency of losses of chromosome 6. Box B shows that the Large Proximal and Large Interstitial subtypes both have high levels of aneuploidy of chromosome 7. Box C shows high rates of gains at chromosome 9 in the Extensive deletions. Box D demonstrates a high number of gains of chromosome 11 in the Small Interstitial subtype. Box E highlights the gains of chromosome 12p in three subtypes: Large Proximal, Large Terminal and Extensive. Box F shows a progressive increase of chromosome 13 deletions with whole chromosome losses in Extensive deletion type. Files obtained in Nexus Copy Number v8.0 (Biodiscovery)