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Table 1 Results of a direct segregation analysis of pedigree showing the probability of recurrence estimates obtained separately for: liveborn with unbalanced karyotype, stillbirth/early neonatal death, miscarriage, and child with normal phenotype

From: Limited survivability of unbalanced progeny of carriers of a unique t(4;19)(p15.32;p13.3): a study in multiple generations

Carrier Parental sex Liveborn with unbalanced karyotype Stilbirth Miscarriage Child with normal phenotype Pregnancies Rate
U u S s M m N n P p u/p s/p m/p n/p
   1 0 1 1 3 3 2 2 7 6 0/6 1/6 3/6 2/6
III:1 PAT - - - - 1 1 4 3 5 4 −/4 −/4 1/4 3/4
II:6 MAT - - - - - - 2 1 2 1 −/1 −/1 −/1 1/1
IV:8 MAT 1 1 1 1 2 2 - - 4 4 1/4 1/4 2/4 −/4
III:8 MAT - - - - - - 2 2 2 2 −/2 −/2 −/2 2/2
II:8 MAT - - - - - - 5 5 5 5 −/5 −/5 −/5 5/5
I:1;I:2 MAT?
PAT?
- -    - - 6 5 6 5 −/5 −/5 −/5 5/5
  Total 2 1 2 2 6 6 21 18 31 27 1/27 2/27 6/27 18/27
          Probability (%) 3.7±3.6 7.4±5.0 22.2±8.0 66.7±9.1
  1. U number of children with unbalanced karyotype, u number of children with unbalanced karyotype after ascertainment correction, S number of stillbirth, s number of stillbirth after ascertainment correction, M number of miscarriages, m number of miscarriages after ascertainment correction, N number of children with normal phenotype, n number of children with normal phenotype after ascertainment correction, P total number of pregnancies, p total number of pregnancies after ascertainment correction