Fig. 5
From: Inherent variability of cancer-specific aneuploidy generates metastases
Cellular morphologies and karyotypes of medulloblastoma M-458 (a, b) and a corresponding metastasis M-425 (c, d). The comparisons show again that the primary cancer M-458 and the corresponding metastasis M-425 have similar, but distinct cell morphologies (a, c) and karyotypes (b, d). Some of the metastatic M-425 cells grew in suspension (One reason, why M-425 was named the metatasis. See note above in this section.), while the rest was attached to the culture dish. The karyotypes of both the primary cancer and the metastasis are hyper-triploid and have similar numbers of chromosomes and of aneusomies. But they also differ in the total numbers of chromosomes and in the structures of some individual marker chromosomes (see Tables 1 and 2). The cells were propagated and karyotyped as described for Fig. 2