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Table 5 Observed and expected frequencies of involvement of the studied chromosomes in MMC– and BLM-induced MN

From: Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human leukocytes

Chromosome number Observed (wcp + MN) Expected (wcp + MN) Observed (wcp - MN) Expected (wcp - MN) χ 2 Total MN
  MMC-induced MN
8 31* 60 1,231 1,202 14.715 1,262
15 32 42 1,230 1,220 2.461 1,262
20 16 26 1,246 1,236 3.926 1,262
  BLM-induced MN
1 114 112 1,273 1,375 0.037 1,387
9 65 63 1,222 1,324 0.066 1,387
16 35 41 1,252 1,346 1.410 1,387
  1. wcp + MN, wcp signal-positive MN; wcp- MN, wcp signal-negative MN
  2. *p < 0.01 when compared with expected value (χ 2 test)
  3. Comparison of observed and expected frequencies of micronucleation using χ 2 test revealed that chromosome 8 is involved in MMC-induced MN (wcp positive) less frequently than expected (*p < 0.01). Implementation of χ 2 test demonstrated that chromosomes 1, 9 and 16 are involved in BLM-induced MN as expected proportionally to their length (p > 0.05)