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Table 5 Observed and expected frequencies of involvement of the studied chromosomes in MMC– and BLM-induced MN

From: Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human leukocytes

Chromosome number

Observed (wcp + MN)

Expected (wcp + MN)

Observed (wcp - MN)

Expected (wcp - MN)

χ 2

Total MN

 

MMC-induced MN

8

31*

60

1,231

1,202

14.715

1,262

15

32

42

1,230

1,220

2.461

1,262

20

16

26

1,246

1,236

3.926

1,262

 

BLM-induced MN

1

114

112

1,273

1,375

0.037

1,387

9

65

63

1,222

1,324

0.066

1,387

16

35

41

1,252

1,346

1.410

1,387

  1. wcp + MN, wcp signal-positive MN; wcp- MN, wcp signal-negative MN
  2. *p < 0.01 when compared with expected value (χ 2 test)
  3. Comparison of observed and expected frequencies of micronucleation using χ 2 test revealed that chromosome 8 is involved in MMC-induced MN (wcp positive) less frequently than expected (*p < 0.01). Implementation of χ 2 test demonstrated that chromosomes 1, 9 and 16 are involved in BLM-induced MN as expected proportionally to their length (p > 0.05)
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Molecular Cytogenetics

ISSN: 1755-8166