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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Prenatal diagnosis and genetic counseling in a fetus associated with risk of Angelman syndrome with a small supernumerary marker chromosome derived from chromosome 22

Fig. 2

The origin of marker chromosome characterized by centromeric FISH and subcentromeric FISH. a: The sSMC wasn’t derived from chromosome 14. The centromeric probe specific for chromosome 14 / 22(D14/22Z1 blue) and a probe specific for all acrocentric p-arms (acro-p red) were present on the marker chromosome. But the centromere-near probe in 14q11.2(RP11-332 N6 green) was not detected on the marker chromosome. b: The sSMC originated from chromosome 22 and was an inv dup(22)(q11.1). The centromeric probe specific for chromosome 22(D22Z4 red) and a probe specific for all acrocentric p-arms (acro-p blue) were present on the marker chromosome. A centromere-near probe in 22q11.21(RP11-172D7 green) was not detected.14:chromosome 14; 22: chromosome 22; mar: sSMC

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Molecular Cytogenetics

ISSN: 1755-8166