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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: Prenatal diagnosis and genetic counseling in a fetus associated with risk of Angelman syndrome with a small supernumerary marker chromosome derived from chromosome 22

Fig. 1

Results of karyotypes and FISH using the 15 dual color DNA probes. a–c: The results of karyotypes from the mother (a), the fetus (b) and the proband (c) showed the sSMC in the proband and the fetus were maternally inherited. The black arrow indicates the sSMC. d–f: The results of FISH using the 15 dual color DNA probes showed that there was no deletion in chromosome 15q11-13 observed both in the mother (d) and in the fetus (e) and that there was no additional centromeric signal of chromosome 15 in the three cases. The white arrow(↓) shows the loss of chromosome 15q11-13 and the white arrow to left (←) indicates normal chromosome 15 in the proband (f). The orange signals indicate chromosome 15q11-13 and 15q22-24(used as control probe), the green signal indicates the centromere of chromosome 15. a, d: the mother of proband; b, e: the fetus; c, f: the proband

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Molecular Cytogenetics

ISSN: 1755-8166