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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: GSTM1 copy number variation in the context of single nucleotide polymorphisms in the human GSTM cluster

Fig. 2

GSTM1 copy number distribution and haplotype structure of the GSTM cluster genomic region in a combined Russian sample. SNP haplotypes in the region of the GSTM cluster are shown. The gap in the center of the plot indicates the edges of the GSTM1 deletion. The branch points represent SNPs at which flanking haplotypes diverge because of mutation or recombination. The thickness of the branches corresponds to the frequency of haplotypes. Blue to red color intensity indicates the allele frequency of individual SNPs used to define the haplotypes, where the major allele is bluer, and the minor allele is redder. The color of the “leaves” at the ends of the branches indicates the GSTM1 state of the chromosomes: green, no copies of GSTM1 (deleted gene; CN0); blue, one functional copy of GSTM1 (CN1)

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Molecular Cytogenetics

ISSN: 1755-8166