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Fig. 4 | Molecular Cytogenetics

Fig. 4

From: Preferential Y-Y pairing and synapsis and abnormal meiotic recombination in a 47,XYY man with non obstructive azoospermia

Fig. 4

Unsynapsed regions of the sex chromosomes are stained positive for γH2AX while synapsed regions remained unstained in spermatocytes of 47,XYY male. Pachytene spermatocytes immunostained for γ-H2AX (Green), MLH1 (Green), CREST (Blue) and SYCP3 (Red). a γ-H2AX signals are not detected in the region of synapsed YY, but detected in unsynapsed regions of Y chromosomes and X chromosome. b, c Enlarged area from (a). d A schematic configuration of the sex chromosomes from the cell shown in b and c. e γ-H2AX signals are not visible on the completely synapsed YY but visible around X chromosome. f Enlarged area from (e). g A schematic configuration of the sex chromosomes from the cell shown in e and f

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