Table 2 Results of karyotype analysis, FISH and IGVH mutation status of 40 CLL patients
Case no. | Karyotype | FISH analysis | Mutational status IGVH | |||
|---|---|---|---|---|---|---|
del 13q14 | tris 12 | del ATM | del TP53 | |||
Cases with monoallelic deletion 13q14 | ||||||
1. | 46,XY[10] | 97 % | N | N | N | UM |
2. | - | 97 % | N | 88 % | N | UM |
3. | 46,XY,del(13)(q14q32)[2]/46,XY[17] | 96 % | N | N | N | UM |
4. | 45,XY,-6,-13,+mar [6]/ 46,XY [1] | 95 % | N | N | N | UM |
5. | 46,XX,del(11)(q21)[10] | 95 % | N | 99 % | N | UM |
6. | 46,XX[15] | 94 % | N | N | N | UM |
7. | 46,XX,t(?;14)(?;q32),?add(18)(q23)[3]/46,XX[7] | 93 % | N | N | N | M |
8. | 46,XY[12] | 90 % | N | 92 % | N | UM |
9. | 46,XY[20]/45 ~ 46,XY,-10[2], +1 ~ 3mar[cp3] | 90 % | N | 92 % | N | UM |
10. | - | 86 % | N | N | N | M |
11. | 47,XY,+?2,-8,+mar[3]/46,XY[37] | 84 % | N | N | N | UM |
12. | 46,XY,del(13)(q14q14)[9]/46,XY[11] | 80 % | N | N | N | UM |
13. | - | 71 % | N | N | N | M |
14. | 46,XY,del(11)(q21q24)[3]/46,XY[4] | 71 % | N | 81 % | N | UM |
15. | 46,XX[38] | 69 % | N | N | N | M |
16. | 46,XY,del(11)(q23)[7]/46,XY,-13,+mar[7]/ 46,XY[4] | 63 % | N | 20 % | N | UM |
17. | 46,XY,add(1)(q?44),del(11)(q?14) [2]/46,XY [18] | 58 % | N | 38 % | N | UM |
18. | 47,XY,+12[1]/46,XY[10] | 57 % | N | N | N | UM |
19. | 46,XX[20] | 55 % | N | N | N | UM |
20. | 46,XY[19] | 50 % | N | N | N | UM |
21. | 46,XY[19] | 43 % | N | N | N | UM |
Cases with biallelic deletion 13q14 | ||||||
22. | - | 98 % | N | N | 39 % | UM |
23. | 46,XX,del(11)(q14)[10] | 90 % | N | 90 % | N | UM |
24. | 47,XY,-6,del(12)(p11.2),+del(12)(p11.2), +der(?) (?- > ?cen- > ?::6p25- > 6q21:6q14- > 6qter)[10] /46,XY[2] | 89 % | 76 % | N | N | M |
25. | - | 89 % | N | N | 94 % | UM |
26. | 46,XX[20] | 87 % | N | N | N | M |
27. | 46,XX,t(2;7)(p11;q22)[6]/46,XX[7] | 86 % | N | N | N | M |
28. | 45,X,-X[6]/46,XX[14] | 80 % | N | N | N | M |
29. | 47,XX,+12[9]/46,XX[1] | 56 % | 41 % | N | N | M |
30. | 46,XY,t(9;13)(q34;q14)[17]/46,XY[1] | 90 % 10 % | N | N | N | UM |
31. | 46,XX[20] | 67 % 19 % | N | N | N | M |
32. | 46,XX,+12,[6]/46,XX[5] | 44 % 32 % | 80 % | N | N | M |
33. | 46,XX,t(2;13)(q37;q14)[6]/46,XX[3] | 40 % 53 % | N | N | N | UM |
34. | 46,XY[13] | 40 % 40 % | N | N | N | M |
35. | 44 ~ 47,XX,+12[7]/46,XX[5] | 35 % 7 % | 74 % | N | N | M |
36. | 45,XY,der(17)t(17;18)(p11.2;q11.2),-18[2]/ 45,idem,-11,+mar[6] | 26 % 70 % | N | 27 % | 93 % | UM |
37. | 46,XX[20] | 23 % 21 % | N | N | N | M |
38. | 46,XX,del(5)(p11.2)[2]/46,XX[14] | 20 % 62 % | N | N | N | M |
39. | 46,XY,del(11)(q21)[7]/45,idem,-13 [4]/46,XY[4] | 19 % 76 % | N | 85 % | N | UM |
40. | 46,XX[5] | 11 % 86 % | N | 95 % | N | UM |