Fig. 17
From: Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells
Karyotype arrays of four morphologically distinct neoplastic colonies derived from SV40-infected mouse embryo cells: second pair of two. To test the theory that individual clonal karyotypes encode individual phenotypes, the karyotypes of two of four mouse colonies, namely F10 and F11 were compared here. a shows that F10 has a hyper-tetraploid karyotype with 96 chromosomes that were 70–100 % clonal. Accordingly, the F10 chromosomes formed an F10-specific quasi-clonal array, which is different from those of F1 and F9. b shows that F11 has a near tetraploid karyotype with an average number of 78 chromosomes, which were 55–100 % clonal. Accordingly the F11 chromosomes also formed an individual quasi-clonal array, which is different from those of all three sister colonies, F1, F9, and F10 tested above. The individual karyotypes of the four phenotypically distinct mouse clones thus support the theory that individual karyotypes encode the individual phenotypes of neoplastic clones