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Table 3 Summary of 12 cases with double inv(3)(q21q26.2) reported in the literature

From: Double inv(3)(q21q26.2) in acute myeloid leukemia is resulted from an acquired copy neutral loss of heterozygosity of chromosome 3q and associated with disease progression

Age (year)/gender

Blast (%)

Diagnosis

Cytogenetic findings

Overall survival (mo)

Reference

55/F

NA

MDS

46,XX,inv(3)x2

24

Walter [10]

NA/F

NA

BP-CML

46,XX,inv(3)x2,t(9;17;22)

NA

Levy [12]

80/M

NA

AML-M1

46,XY,inv(3)x2

13

Secker-Walker [8]

39/M

NA

AML-M4

45,XY,inv(3)x2,-7

3

Secker-Walker [8]

83/F

63

AML

45,XX,inv(3)x2,-7

NA

Lee [7]

65/M

49

AML-M4

46,XY,inv(3)x2,

24

Lahortiga [9]

36/M

NA

CML

46,XY,inv(3)x2,7q-

NA

Toydemir [11]

62/M

14

AML-M1

45,XY,inv(3)x2,-7

9

De Braekeleer [6]

67/F

35

AML

46,XX,inv(3),5q+/45,idem,-7/45,idem,inv(3),-7

4

De Braekeleer [6]

72/M

79

AML-M6A

46,XY,inv(3)(q21q26.2),del(7)(q22)/46,XY,inv(3)(q21q26.2)x2

23

Patient 1

64/F

23

AMML

46,XX,inv(3)x2

12

Patient 2

56/F

54

AML

46,XX,inv(3)x2/45,idem,-7

5

Patient 3

  1. NA not available, MDS myelodysplastic syndrome, AML acute myeloid leukemia, CML chronic myelogeneous leukemia, BP blast phase, AMML acute myelomonocytic leukemia, Mo months