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Table 3 Summary of 12 cases with double inv(3)(q21q26.2) reported in the literature

From: Double inv(3)(q21q26.2) in acute myeloid leukemia is resulted from an acquired copy neutral loss of heterozygosity of chromosome 3q and associated with disease progression

Age (year)/gender Blast (%) Diagnosis Cytogenetic findings Overall survival (mo) Reference
55/F NA MDS 46,XX,inv(3)x2 24 Walter [10]
NA/F NA BP-CML 46,XX,inv(3)x2,t(9;17;22) NA Levy [12]
80/M NA AML-M1 46,XY,inv(3)x2 13 Secker-Walker [8]
39/M NA AML-M4 45,XY,inv(3)x2,-7 3 Secker-Walker [8]
83/F 63 AML 45,XX,inv(3)x2,-7 NA Lee [7]
65/M 49 AML-M4 46,XY,inv(3)x2, 24 Lahortiga [9]
36/M NA CML 46,XY,inv(3)x2,7q- NA Toydemir [11]
62/M 14 AML-M1 45,XY,inv(3)x2,-7 9 De Braekeleer [6]
67/F 35 AML 46,XX,inv(3),5q+/45,idem,-7/45,idem,inv(3),-7 4 De Braekeleer [6]
72/M 79 AML-M6A 46,XY,inv(3)(q21q26.2),del(7)(q22)/46,XY,inv(3)(q21q26.2)x2 23 Patient 1
64/F 23 AMML 46,XX,inv(3)x2 12 Patient 2
56/F 54 AML 46,XX,inv(3)x2/45,idem,-7 5 Patient 3
  1. NA not available, MDS myelodysplastic syndrome, AML acute myeloid leukemia, CML chronic myelogeneous leukemia, BP blast phase, AMML acute myelomonocytic leukemia, Mo months