Table 1 KL-BOBs™ and conventional cytogenetic characteristics
KL-BOBs™ | GTG Karyotype | |
|---|---|---|
Tissue Culture | Not necessary | Necessary, 50 % fails to grow |
Final result | 24–48 h | 1 month |
Interpretation of the results | Friendly-software | Skilled and trained lab-person |
Throughput-technique | High | Low |
Technical problems | DNA Extraction (very rare), maternal contamination | Bacterial infection, maternal cell contamination, tissue maceration, poor chromosomal morphology |
Chromosomal abnormalities detection | Aneuploides (representing 90 % of the pregnancy losses) | Numerical, structural, triploidies and tetraploidies |
Mosaics | Above 15–20 % | At leaste25 good quality metaphases |
Cost efficient | Cost efficient | Not-cost efficient |