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Table 1 In situ hybridization, microarray and cytogenetic data of the patients

From: Microarray-based genomic profiling and in situ hybridization on fibrotic bone marrow biopsies for the identification of numerical chromosomal abnormalities in myelodysplastic syndrome

Group Patient ID Sex Age (years) Diagnosis Fibrosis FISH (BM biopsy) Array based karyotype (BM biopsy) Karyotype (BM aspirate)
1 4902 M 63 RCMD no not done del(16)(q11q23) 46,XY,del(16)(q11q23)[4]/46,XY[6]
  4519 F 59 AML no loss 7 (44%) del(3)(p24p22),del(3)(p14p12),del(4)(p15),dup(5)(p11),del(5)(q11q35),del(7)(p14p11), del (7)(q11q26),del(10) (q11q24),del(10)(q25q26),dup(22)(q11) 45,XX,del(5)(q13q33),-7[4]/46,XX[16]
  4898 F 42 RCMD no loss 7 (50%) −7,+21,+22 45,XX,-7[4]/47,sl,+21,+22[5]/46,XX[1]
  4893 M 80 RAEB-1 no trisomy 8 (50%) +8 47,XY,+8[10]
  4895 F 59 RCMD-RS no trisomy 8 (23%) +8 47,XX,+8[6]/46,XX[4]
  4896 M 72 RCMD no loss 8 (47%) loss 7 (50%) del(5)(q21q31),-7 44,XY,del(5)(q15q33),-7,dic(15;17)(p11;p11),-18,der(21;22)(q10;q10),+2mar[cp8]/46,XY[2]
  4912 M 64 RAEB-2 no not done +8,+21 47,XY,+21[1]/48,sl,+8[9]
2 4522 M 57 RCMD grade 3 loss 20q (32%) trisomy 8 (18%) del(3)(p24q25),del(5)(q14q34),del(6)(p24q16), del(7)(q11q32),+8,del (20)(q11) 40~44,XY,-5,-6,-7,+8,-20,+4mar[cp7]/46,XY[3]
  4894 M 67 RCMD grade 2 loss 20q (77%) del(20)(q11q13) 46,XY,del(20)(q13)[10]
  4899 M 58 RAEB grade 3 not done del(2)(p23),del(4)(p12),del(4)(q12q13.2), del(5)(q14q35),del(7) (q21q36),del(12)(p12p13),del(20)(q11q13) 44~47,XY,-2,-2,-4,del(4)(q31),-5,-7,add(9)(q34),add(12)(p13),−13,-15,-16,-17,add(17)(p13),del(20)(q11),+3~7mar[cp8]/46,XY[2]
  4903 M 58 AML patchy fibrosis faillure no CNA 44~47,XY,-2,-2,-4,-4,+6,-7,-9,-10,-13,-13,-17,add(17)(p13),−19,del(20)(q11),+21,+21,+4~8mar[cp8]/46,XY[2]
  4523 F 58 RAEB-2 grade 3 loss 7 (46%) loss 5 (29%) del(5)(q14q33),-7 45,XX,t(4;17;20)(q31;q12;q13),del(5)(q13q33),-7[10]
  4520 M 70 RAEB-2 grade 3 loss 7 (61%) loss 5 (40%) -Y,del(5)(q11q34),-7,del(17)(p13),-18 42~44,X,-Y,-5,-7,+?12,-13,add(17)(p13),-20,-21,+3mar[cp13]
  4521 F 59 RCMD grade 2 loss 5q (19%) del(4)(q24q26),del(5)(q13q35),del(6)(q11q21), del(7)(q11),del (17)(p13.1p13.3) 45~46,XX,add(1)(q32),del(5)(q?22q33),del(6)(p22),add(7)(q11),-10,-13,del(17)(p11),+2~3mar[cp10]
3 4904 F 60 RAEB-2 no not done no CNA 46,XX[20]
  4906 F 64 vit. B12 deficiency no not done no CNA 46,XX[23]
  4897 M 71 hypoplastic AML no not done no CNA 46,XY[20]
  4518 F 45 pure red cell aplasia no loss 7q (34%) no CNA 46,XX[20]
  4890 M 58 RCMD no not done no CNA 46,XY[20]
  4892 F 63 RCMD-RS no not done no CNA 46,XX,t(3;3)(q21;q26)[11]
  4900 F 63 RAEB-1 no not done no CNA 46,XX[20]
  1. RCMD = refractory cytopenia with multi lineage dysplasia, RAEB = refractory anemia with excess of blasts, RCMD-RS = RCMD with ringsideroblasts, AML = acute myeloid leukemia, no CNA = no copy number abnormality, BM = bone marrow.