Angelman Syndrome due to familial translocation: unexpected additional results characterized by Microarray-based Comparative Genomic Hybridization

Table 1 Array CGH results in the five available members family

Family member		Chromosome	Imbalanced	Position 1	Position 2	Size
III-1	Proband	10q26.3	deletion	134,339,232	135,404,471	1.06
III-1	Proband	15q11.1-q11.2	deletion	20,481,702	25,582,821	5.1
II-2	Mother	10	normal	---	---	---
II-2	Mother	15	normal	---	---	---
I-1	Grandfather	10	normal	---	---	---
I-1	Grandfather	15q11.1-q11.2	deletion	20,481,702	22,509,254	2.03
II-3	Uncle	10q26.3	duplication	134,339,232	135,404,471	1.06
II-3	Uncle	15q11.2	duplication	22,784,523	25,582,821	2.8
III-2	Cousin	10q26.3	duplication	134,339,232	135,404,471	1.06
		15q11.1-q11.2	duplication	20,481,702	25,582,821	5.1
		Xp22.31	duplication	6,552,712	8,115,153	1.56

ISSN: 1755-8166