Non-to-scale diagram to explain the chromosomal rearrangement observed by Saglio et al.
A) Normal 9 and 22 chromosomes displaying some sequences of interest. Aqua box represents the ABL1-intron 1 sequence. Dark-blue box denotes the ABL1 sequences downstream from intron 1. The depicted BCR gene sequences are split by the breakpoint. Duplicons were oriented according to information obtained from  and from the Database of Genomic Variants [http://dgv.tcag.ca/dgv/app/home (GRCh37/hg19)]. B) Proposed constitutional derivative chromosome 9 (der(9)c) carrying an inversion and a direct duplication. C) Hypothetical ancestral chromosome by which the proposed der(9)c could have been originated. D) Non-allelic homologous annealing − mainly at regions of duplicons − followed by recombination at specific points, renders the t(9;22) and a circular acentric fragment. For full explanation see text.