Figure 6

Karyotype array of the clonal neoplasia RMT-CN 65, which evolved from a non-clonal rat mammary hyperplasia. The karyotype array of the clonal neoplasia RMT-CN 65 was prepared from a three-dimensionally growing focal colony that had evolved from a culture of the non-clonal aneuploid mammary hyperplasia RMT 65 within several months in culture (Table 2). The karyotype array and the attached table show that the numbers of RMT-CN 65 chromosomes per cell were quasi-clonal, averaging 50 ± 3. The data also show that the chromosome copy numbers were 83-100%-clonal, and that the RMT-CN 65 karyotype is individually distinct from those shown in Figures 3 and 5.