A new bridge between experimental cytogenetic analyses of mammary precancers and cancers of rats and their relevance to clinical distinctions between preneoplastic dysplasias and neoplastic carcinomas of humans from Alfred Boecking (Duesseldorf/Dueren, Germany).
Peter Duesberg, University of California Berkeley
6 May 2015
A new Letter-to-the editor by Alfred Boecking (Duesseldorf/Dueren, Germany), "Comparability of tumor-cytogenetics and DNA cytometry" (Mol Cyogenet (2015) 8:28) builds a most eye-opnening brigde between human and animal cancers: It explains the amazing similarities between our cytogenetic and phenotypic data on the non-clonal karyotypes of preneoplastic mammary hyperplasias and the clonal individual karyotypes of mammary carinomas of experimental rats (Bloomfield et al. (2014), "Karyotypic evolutions of cancer species in rats .. after nitrosourea", Mol Cytogenet, 7: 2014) and the clincal distinctions between human preneoplastic dysplasias and cancers - based on clinical DNA content and cell morpholgy tests.
Boeckings letter is for us "molecular biologists" the Rosetta stone, we have been looking for envain in the currently popular cancer and biology texts here in the US.
With the help of Boecking's letter, we hope now to understand better the gap between "molecular" lab reseach on animals and in cell culture and further studies with clinical relevance from us labrats.
Hopefully we will even find now clinicians able to provide us cell cultures of human tumor biopsies and willing to collaborate with us soon.
Sincerely,
Peter Duesberg
Competing interests
There are "unfortunately" no competing commercial interests with considerations other than our paper's validity or importance.
Molecular Cytogenetics
A new bridge between experimental cytogenetic analyses of mammary precancers and cancers of rats and their relevance to clinical distinctions between preneoplastic dysplasias and neoplastic carcinomas of humans from Alfred Boecking (Duesseldorf/Dueren, Germany).
6 May 2015
A new Letter-to-the editor by Alfred Boecking (Duesseldorf/Dueren, Germany), "Comparability of tumor-cytogenetics and DNA cytometry" (Mol Cyogenet (2015) 8:28) builds a most eye-opnening brigde between human and animal cancers: It explains the amazing similarities between our cytogenetic and phenotypic data on the non-clonal karyotypes of preneoplastic mammary hyperplasias and the clonal individual karyotypes of mammary carinomas of experimental rats (Bloomfield et al. (2014), "Karyotypic evolutions of cancer species in rats .. after nitrosourea", Mol Cytogenet, 7: 2014) and the clincal distinctions between human preneoplastic dysplasias and cancers - based on clinical DNA content and cell morpholgy tests.
Boeckings letter is for us "molecular biologists" the Rosetta stone, we have been looking for envain in the currently popular cancer and biology texts here in the US.
With the help of Boecking's letter, we hope now to understand better the gap between "molecular" lab reseach on animals and in cell culture and further studies with clinical relevance from us labrats.
Hopefully we will even find now clinicians able to provide us cell cultures of human tumor biopsies and willing to collaborate with us soon.
Sincerely,
Peter Duesberg
Competing interests
There are "unfortunately" no competing commercial interests with considerations other than our paper's validity or importance.