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Association of Vitamin D3 levels with glycemic control in Type 2 diabetes subjects from Gujarati population-India
© Majumder et al; licensee BioMed Central Ltd. 2014
Published: 21 January 2014
Considering the active role of Vitamin D3 in the functional regulation of pancreatic β-cells, present study was carried out to know the occurrence of Vitamin D3 deficiency in Type 2 diabetic [T2D] and non-diabetic subjects and demonstrate its influence on glycemic control.
Materials and methods
This prospective study comprises of 508 individuals (including 210 T2D & 298 controls). All subjects were categorized into 3 groups according to Vitamin D3 levels. Group-I: included 171 individuals (61 T2D out of 171) with normal Vitamin D3 concentration (≥25 nmol/l), group-II: included 264 subjects (118 T2D out of 264)with mild to moderately Vitamin D3 deficiency (15-24.9 nmol/l) and group-III included 73 subjects (31 T2D out of 73) having severe Vitamin D3 deficiency (≤14.9 nmol/l). Vitamin D3 and glycosylated hemoglobin [HbA1C] level was analyzed for all the subjects.
Overall 66.34% subjects (both T2D & Controls) were found to have Vitamin D3 deficiency. This was more common in T2D patients (71%)(mean±SD Vitamin D3 level was 17.77±7.19nmol/L) as compared to controls (63%) (mean±SD Vitamin D3 level was 24.38 ± 9.30nmol/L)(p<0.05).Female subjects were more prone for Vitamin D3 deficiency as compared to male (71.09% vs 61.09%, p<0.03) subjects. Moreover, a gradual increase in mean HbA1C level was observed as Vitamin D3 level when reduced from its normal level in T2D subjects (7.95- 9.08% in group-I through group-III) [βHbA1C, Vit. D3= -0.07, r = -0.28, p<2.73×10-5]. No such changes in mean HbA1C level were observed in controls.
Present study demonstrates the high prevalence (66.34%) of Vitamin D3 deficiency in Gujarati population from India, more so for subjects with T2D. It is likely that Vitamin D3 has a role in regulating insulin sensitization; resulting in poor glycemic control in subjects with low Vitamin D3 levels. This study also indicates that females are likely to be at a higher risk for Vitamin D3 deficiency compared to male in T2D and control subjects.
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