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  • Open Access

Association of Vitamin D3 levels with glycemic control in Type 2 diabetes subjects from Gujarati population-India

  • 1Email author,
  • 1,
  • 1,
  • 1,
  • 2,
  • 3,
  • 4 and
  • 1
Molecular Cytogenetics20147 (Suppl 1) :P36

https://doi.org/10.1186/1755-8166-7-S1-P36

  • Published:

Keywords

  • Vitamin D3
  • HbA1C
  • Type 2 Diabetes

Background

Considering the active role of Vitamin D3 in the functional regulation of pancreatic β-cells, present study was carried out to know the occurrence of Vitamin D3 deficiency in Type 2 diabetic [T2D] and non-diabetic subjects and demonstrate its influence on glycemic control.

Materials and methods

This prospective study comprises of 508 individuals (including 210 T2D & 298 controls). All subjects were categorized into 3 groups according to Vitamin D3 levels. Group-I: included 171 individuals (61 T2D out of 171) with normal Vitamin D3 concentration (≥25 nmol/l), group-II: included 264 subjects (118 T2D out of 264)with mild to moderately Vitamin D3 deficiency (15-24.9 nmol/l) and group-III included 73 subjects (31 T2D out of 73) having severe Vitamin D3 deficiency (≤14.9 nmol/l). Vitamin D3 and glycosylated hemoglobin [HbA1C] level was analyzed for all the subjects.

Results

Overall 66.34% subjects (both T2D & Controls) were found to have Vitamin D3 deficiency. This was more common in T2D patients (71%)(mean±SD Vitamin D3 level was 17.77±7.19nmol/L) as compared to controls (63%) (mean±SD Vitamin D3 level was 24.38 ± 9.30nmol/L)(p<0.05).Female subjects were more prone for Vitamin D3 deficiency as compared to male (71.09% vs 61.09%, p<0.03) subjects. Moreover, a gradual increase in mean HbA1C level was observed as Vitamin D3 level when reduced from its normal level in T2D subjects (7.95- 9.08% in group-I through group-III) [βHbA1C, Vit. D3= -0.07, r = -0.28, p<2.73×10-5]. No such changes in mean HbA1C level were observed in controls.

Conclusion

Present study demonstrates the high prevalence (66.34%) of Vitamin D3 deficiency in Gujarati population from India, more so for subjects with T2D. It is likely that Vitamin D3 has a role in regulating insulin sensitization; resulting in poor glycemic control in subjects with low Vitamin D3 levels. This study also indicates that females are likely to be at a higher risk for Vitamin D3 deficiency compared to male in T2D and control subjects.

Authors’ Affiliations

(1)
FRIGE House, FRIGE’s Institute of Human Genetics, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India
(2)
Department of Diabetes and Endocrinology, Sterling Hospital, Ahmedabad, 380052, India
(3)
Gujarat Diabetic Association, Ahmedabad, 380007, India
(4)
Kasturba Health Society, Medical Research Centre, Mumbai, 400056, India

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