Skip to content

Advertisement

  • Poster presentation
  • Open Access

Role of sarcomeric gene polymorphisms on left ventricular dysfunction in coronary artery disease patients

  • 1Email author,
  • 1,
  • 1,
  • 2,
  • 3,
  • 3 and
  • 1
Molecular Cytogenetics20147(Suppl 1):P112

https://doi.org/10.1186/1755-8166-7-S1-P112

Published: 21 January 2014

Keywords

  • Coronary Artery Disease
  • Ejection Fraction
  • Congestive Heart Failure
  • Cardiomyopathy
  • Gene Polymorphism

Background

Coronary artery disease (CAD) is a major cardiac disease in humans. Many CAD patients develop left ventricle dysfunction (LVD), leading to congestive heart failure. Mutations in several genes including those encoding sarcomeric proteins such as MYBPC3, TNNT2, and TTN are common genetic cause of hereditary cardiac myopathies. An intronic 25-bp deletion in MYBPC3 at 3’ region is associated with dilated (DCM) and hypertrophic (HCM) cardiomyopathies in Southeast Asia. We sought to determine the role of MYBPC3 25bp, TNNT2 5bp and TNN 18bp ins/del polymorphisms on LVD in CAD patients.

Methods and results

The study included 200 healthy controls and 988 consecutive patients with angiographically confirmed CAD. Among them, 253 with reduced ejection fraction (LVEF <45%) were categorized as having LVD. MYBPC3 25bp, TNNT2 5bp and TNN 18bp ins/del polymorphisms were determined by polymerase chain reaction. Our results showed that MYBPC3 25bp deletion was significantly associated with CAD as well as LVD (healthy controls v/s CAD; p value = 0.003; OR=4.08, healthy controls v/s LVD; p value < 0.0001; OR=6.67 and Non-LVD v/s LVD; p value = 0.031; OR=1.67). The TNNT2 5bp and TNN 18bp polymorphisms were not found to be associated with CAD (Pvalue=0.580, OR=0.88; Pvalue=0.795, OR=0.91; respectively) or LVD (Pvalue=0.146, OR=1.35; Pvalue=0.935, OR=0.97 respectively) when compared to controls.

Conclusions

The frequency of MYBPC3 DW genotype and D allele was associated with LVD implying that genetic variants of MYBPC3 encoding mutant structural sarcomeric protein could increase susceptibility to left ventricular dysfunction. Therefore, 25bp deletion in MYBPC3 may represent a genetic marker for cardiac failure in CAD patients.

Authors’ Affiliations

(1)
Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow-UP, India
(2)
Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow-UP, India
(3)
Department of CVTS, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow-UP, India

Copyright

© Kumar et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement