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Role of cholecystokinin receptor-A gene polymorphism in development of functional dyspepsia

Background

Functional dyspepsia (FD) is characterized by epigastric pain, burning, early satiety and post-prandial fullness in absence of organic or metabolic causes. Cholecystokinin receptor-A (CCK-AR) is known to modulate satiety signal and delay gastric emptying, which are associated with FD. CCK-AR (rs1800857, T/C) polymorphism is associated with a defective splicing of the primary transcript of CCK-AR mRNA, which may result in the lower expression of the CCK-AR. Therefore, we evaluated the role of genetic polymorphism of CCK-AR gene (rs1800857, T/C) in FD.

Material and methods

237 consecutive patients with FD (Rome III) and 250 healthy controls (HC) were genotyped for CCK-AR gene polymorphism (PCR-RFLP). Patients with FD were sub-classified into epigastric pain syndrome (EPS), post-prandial distress syndrome (PDS) and EPSPDS overlap.

Results

Patients with FD [173 (73%) male, age 38±12-y] were comparable with HC [195 (78%) male, age 37±12-y] with respect to age and gender. 26/237 (11%) had EPS, 55 (23.2%) PDS and 156 (65.8%) EPSPDS overlap. Among 237 patients with FD, CC (variant) genotype of CCK-AR (rs1800857) was infrequent among patients than HC [19 (8%) vs. 46 (18.4%) p=0.001, odds ratio (OR) =0.36, 95% confidence interval (CI) =0.19-0.66]. However, genotypes distribution was comparable among patients with different subtypes of FD (p=0.44).

Conclusions

CC genotype of CCK-AR polymorphism is protective for FD. EPSPDS overlap was common among patients with FD.

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Correspondence to Rajan Singh.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Singh, R., Mittal, B. & Ghoshal, U.C. Role of cholecystokinin receptor-A gene polymorphism in development of functional dyspepsia. Mol Cytogenet 7, P111 (2014). https://doi.org/10.1186/1755-8166-7-S1-P111

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Keywords

  • Confidence Interval
  • Lower Expression
  • Gene Polymorphism
  • Genetic Polymorphism
  • Gastric Emptying