Figure 1
From: Blast crisis Ph+ chronic myeloid leukemia with NUP98/HOXA13 up-regulating MSI2
Molecular and cytogenetic studies. a) Metaphase FISH showed a rearrangement between NUP98 gene at 11p15 and the HOXA cluster at 7p15. b) Breakpoint falls between NUP98 exon 16 and HOXA13 exon 2. Red triangles indicate in-frame splicing variants; yellow triangle an out-of-frame variant. Sequence analysis confirmed the transcript. c) The fusion protein with NUP98 GLFG repeats and the HOXA13 homeodomain (HD).