Figure 5

Functional connections between genes at the 73 critical regions inferred by GRAIL. The double circle plots depict the gene relationships across the abnormal regions by GRAIL based on data source PubMed Text. Outer circle represents abnormal regions, of which the G-band regions with '_del' are denoted deletions and the other regions are duplications. The inner circle stands for genes located in the corresponding regions in the outer circle, and for clear visualization only significant genes (p < 0.001) and their connections are shown. The lines represent pair-wise gene connections, with the thickness of the lines indicating the degree functional similarity.