Figure 3
From: A de novo atypical ring sSMC(22) characterized by array CGH in a boy with cat-eye syndrome
The FISH result with CES critical locus. The FISH analysis with 22q11 locus (a), cohybridization with 22q11 red and 14/22 green centromere probes shows two normal hybridization 22q11 signals on homologues 22 and a duplicated on the sSMC(22) (red arrow). In the smaller box: enlarged red channel with 22q11 region FISH pattern of the normal chromosome 22 and sSMC(22) of the same metaphase showing the opposite localization to the centromere(s) of the two 22q duplicated segments (b). The FISH with aqua acrocentric p-arm probe (c) shows signals on homologues 13, 14, 15, 21, 22 acrocentric chromosomes (white arrowhead), but this hybridization did not yield any signal on the round shaped sSMC(22) ( red arrow).