Figure 1

(A) The cancer genome landscape adapted from Salk et. al.[9] and Wood et. al.[2]. The cancer genome landscape illustrates that the same type of cancer does not share most mutations. The peaks correspond to how frequently a specific gene is mutated in a particular type of cancer. Large peaks, termed “mountains” indicate gene mutations that occur frequently amongst the same type of cancer while small peaks, termed “hills” indicate infrequent gene mutations. (B) In addition to intertumor mutational heterogeneity there exists widespread intratumor mutational heterogeneity. Within a tumor some mutations are present in the majority of single cells, depicted here as “trees”, while other mutations exist only subclonally amongst a tumor, depicted here as “seedlings”.