Table 1 Summary of published data for patients with etv6/abl1 fusion gene
From: Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review
No | Dg | Sex | Age | TKI | Outcome | Eosinophilia | Transcript type | G banding | FISH/ETV6 | FISH/ABL1 | Genome features | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | ALL | F | 22 mo | No | Died | A | na | na | na | na | Papadopoulos et al, 1995 Cancer Research [3] | |
2 | AML-M6 | M | 81 | No | Died | B | t(9;12;14)(q34;p13;q22)/complex karyotype | na | na | na | Golub et al., 1996 Mol & Cellular Biology [7] | |
3 | CML atypical | na | 49 | No | Died | Yes | B | na | na | na | na | Brunel et al., 1995 Leukemia [8] |
4 | CML | M | 32 | No | CR (>3Y) | Yes | B | 46,XY,t(12;14)(p12;q11-13) | 5’ETV6 on 9q34 | ABL1 3’/5’ on 9q34 | na | Andreasson et al., 1997 Genes, Chrom & Ca [9] |
5 | CML | M | 59 | No | Died | Yes | A, | 46,XY,del(6)(p21),?t(9;12)(q34;p12) | 5’ETV6 on 9q34 | ABL1 3’/5’ on 9q34 | na | Van Limbergen et al., 2001 Genes, Chrom & Ca [10] |
6 | T/ALL | M | 4 | No | Died | Yes | A,B | 47,XXYc,del(6)(q15q23) | 5’ETV6 on 9q34 | ABL1 3’/5’ on 9q34 | na | Van Limbergen et al., 2001 Genes, Chrom & Ca [10] |
7 | AML-M6/ CML/MBC | M | 38 | Yes | Died | na | A,B | 46,XY | na | 3’ABL1 on 12p | karyotype evolution | O’Brien et al., 2002 Blood [11] |
8 | CML | M | 53 | No | CR (>6Y) | Yes | A,B | 46,XY | na | ABL1 3’/5’ on 9q34 | na | Lin et al., 2002 Leukemia [12] |
9 | CML | F | 44 | Yes | CR (>6 M) | Yes | 46,XX,t(9;12)(q34;p13) | 5’-3’ETV6 on 9q34 | ABL1 3’/5’ on 9q34 | na | Keung et al., 2002 Ca Gen &Cytogen [13] | |
10 | AML-M1 | M | 29 | No | CR (>20 M post SCT) | Yes | A | 46,XY,t(8;12)(p21;p13) | 5’ETV6 on 8p21 | 3’ABL1 on 8p21 | na | La Starza et al., 2002 Haematologica [14] |
11 | AML-M1 post RAEB | M | 48 | No | Died | Yes | B | 46,XY,t(9;12)(q34;p13) | na | 3’ABL1 on 12p | karyotype evolution | La Starza et al., 2002 Haematologica [14] |
12 | CML-MBC | M | 36 | Yes | Died | Yes | B | 45,XY-7,t(9;12)(q34;q13) | na | 3’ABL1 on 12p | karyotype evolution | Barbouti et al., 2003 Br J Haematol [15] |
13 | CML-LBC | M | 72 | Yes | CR (>12 M) | na | B | 46,XY,t(12;17)(p11.2;p11.2) | 5’ETV6 on 17p | 3’ABL1 on 17p | Tirado et al., 2005 Ca Gen & Cytogen [16] | |
14 | cMPN | F | 65 | No | Died | Yes | A,B | 46,XX ,t(5;9)(q13;q34) | na | 3’ABL1 on 12p | karyotype evolution | Meyer-Monard et al., 2005 Leukemia [17] |
15 | cMPN | M | 57 | No | CR (>15Y) | Yes | na | 46,XY | na | 3’ABL1 on 12p | na | Mozziconacci et al., 2007 Amer J of Haematol [18] |
16 | ALL | M | 30 | Died | A,B | 45,XY,del(1)(q42),-9,-13,add(16)(p1?3),+mar | na | 3’ABL1 on 12p | p16 loss | Baeumler et al., 2008 Ca Gen & Cytogen [19] | ||
17 | CML | F | 24 | Yes | CR (>7 M) | Yes | A | 46,XX | 5’ETV6 on 9q34 | ABL1 3’/5’ on 9q34 | loss ASS-ABL1 exon1 | Kawamata et al., 2008 Genes,Chrom & Ca [20] |
18 | cMPN | F | 61 | Yes | CR (>3Y) | Yes | na | 46,XX | 5’-3’ETV6 on 12p | 3’ABL1 on 12p | na | Nand et al., 2009 Leuk Research [21] |
19 | CML atypical | M | 79 | Yes | Died | Yes | na | 46,XY | 5’-3’ETV6 on 12p | 3’ABL1 on 12p | na | Kelly et al., 2009 Ca Gen &Cytogen [22] |
20 | ALL | F | 33 | Died | No | A,B | 46,XY, der(1)t(1;?) | na | normal | p16/p15 loss | Zuna et al., 2010 Genes,Chrom & Ca [4] | |
21 | ALL | M | 5 | No | CR (>24 M) | Yes | A,B | 46,XY | na | 3’ABL1 on 12p | p16/p15 loss | Zuna et al., 2010 Genes,Chrom &Ca [4] |
22 | ALL | M | 8 mo | Yes | Died | No | A,B | 46,XX,t(8;9;12)(p12;q34;p13) | na | 3’ABL1 on 12p | na | Zuna et al., 2010 Genes,Chrom & Ca [4] |
23 | ALL | F | 8 | Yes | CR( >10 M) | na | A,B | 46.XX | na | 3’ABL1 on 12p? | na | Malone A et al., 2010 Br J Haematol [6] |
24 | CML | M | 36 | Yes | CR(>5Y) | No | 46,XY, t(9;12)(q34;p13) | na | 3’ABL1 on 12p | normal UTX, ASXL1, EZH2, TET2 & IDH1/2 | Perna et al., 2011 Haematologica [24] | |
25 | T/ALL | na | na | na | na | na | na | na | na | na | na | Zhou et al., 2012 Annual Haematology [5] |
26 | T/ALL | na | na | na | na | na | na | na | na | na | na | Zhou et al., 2012 Annual Haematology [5] |
27 | AML | M | 52 | No | Died | Yes | B | 46,XY[20] | 5’-3’ETV6 on 12p | 3’ABL1 on 12p | normal FLT3, cKit & NPM1 | Park J et al., 2013 Acta Haematologica [23] |
28 | B/ALL | F | 25 | No | Died | No | A,B | 46,XX,del(9)(p22), der(10)t(9;10)(q22;p15) | 5’-3’ETV6 on 12p | 3’ABL1 on 12p | na | Park J et al., 2013 Acta Haematologica [23] |
29 | CML | F | 52 | Yes | CR > 12 M | Yes | A,B | 46,XX,t(9;12)(q34;p13) | 5’ETV6 on 9q34 | ABL1 3’/5’ on 9q34 | 37 CNAs | Current study |