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Table 1 Summary of published data for patients with etv6/abl1 fusion gene

From: Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review

No Dg Sex Age TKI Outcome Eosinophilia Transcript type G banding FISH/ETV6 FISH/ABL1 Genome features Reference
1 ALL F 22 mo No Died   A na na na na Papadopoulos et al, 1995 Cancer Research [3]
2 AML-M6 M 81 No Died   B t(9;12;14)(q34;p13;q22)/complex karyotype na na na Golub et al., 1996 Mol & Cellular Biology [7]
3 CML atypical na 49 No Died Yes B na na na na Brunel et al., 1995 Leukemia [8]
4 CML M 32 No CR (>3Y) Yes B 46,XY,t(12;14)(p12;q11-13) 5’ETV6 on 9q34 ABL1 3’/5’ on 9q34 na Andreasson et al., 1997 Genes, Chrom & Ca [9]
5 CML M 59 No Died Yes A, 46,XY,del(6)(p21),?t(9;12)(q34;p12) 5’ETV6 on 9q34 ABL1 3’/5’ on 9q34 na Van Limbergen et al., 2001 Genes, Chrom & Ca [10]
6 T/ALL M 4 No Died Yes A,B 47,XXYc,del(6)(q15q23) 5’ETV6 on 9q34 ABL1 3’/5’ on 9q34 na Van Limbergen et al., 2001 Genes, Chrom & Ca [10]
7 AML-M6/ CML/MBC M 38 Yes Died na A,B 46,XY na 3’ABL1 on 12p karyotype evolution O’Brien et al., 2002 Blood [11]
8 CML M 53 No CR (>6Y) Yes A,B 46,XY na ABL1 3’/5’ on 9q34 na Lin et al., 2002 Leukemia [12]
9 CML F 44 Yes CR (>6 M) Yes   46,XX,t(9;12)(q34;p13) 5’-3’ETV6 on 9q34 ABL1 3’/5’ on 9q34 na Keung et al., 2002 Ca Gen &Cytogen [13]
10 AML-M1 M 29 No CR (>20 M post SCT) Yes A 46,XY,t(8;12)(p21;p13) 5’ETV6 on 8p21 3’ABL1 on 8p21 na La Starza et al., 2002 Haematologica [14]
11 AML-M1 post RAEB M 48 No Died Yes B 46,XY,t(9;12)(q34;p13) na 3’ABL1 on 12p karyotype evolution La Starza et al., 2002 Haematologica [14]
12 CML-MBC M 36 Yes Died Yes B 45,XY-7,t(9;12)(q34;q13) na 3’ABL1 on 12p karyotype evolution Barbouti et al., 2003 Br J Haematol [15]
13 CML-LBC M 72 Yes CR (>12 M) na B 46,XY,t(12;17)(p11.2;p11.2) 5’ETV6 on 17p 3’ABL1 on 17p   Tirado et al., 2005 Ca Gen & Cytogen [16]
14 cMPN F 65 No Died Yes A,B 46,XX ,t(5;9)(q13;q34) na 3’ABL1 on 12p karyotype evolution Meyer-Monard et al., 2005 Leukemia [17]
15 cMPN M 57 No CR (>15Y) Yes na 46,XY na 3’ABL1 on 12p na Mozziconacci et al., 2007 Amer J of Haematol [18]
16 ALL M 30   Died   A,B 45,XY,del(1)(q42),-9,-13,add(16)(p1?3),+mar na 3’ABL1 on 12p p16 loss Baeumler et al., 2008 Ca Gen & Cytogen [19]
17 CML F 24 Yes CR (>7 M) Yes A 46,XX 5’ETV6 on 9q34 ABL1 3’/5’ on 9q34 loss ASS-ABL1 exon1 Kawamata et al., 2008 Genes,Chrom & Ca [20]
18 cMPN F 61 Yes CR (>3Y) Yes na 46,XX 5’-3’ETV6 on 12p 3’ABL1 on 12p na Nand et al., 2009 Leuk Research [21]
19 CML atypical M 79 Yes Died Yes na 46,XY 5’-3’ETV6 on 12p 3’ABL1 on 12p na Kelly et al., 2009 Ca Gen &Cytogen [22]
20 ALL F 33   Died No A,B 46,XY, der(1)t(1;?) na normal p16/p15 loss Zuna et al., 2010 Genes,Chrom & Ca [4]
21 ALL M 5 No CR (>24 M) Yes A,B 46,XY na 3’ABL1 on 12p p16/p15 loss Zuna et al., 2010 Genes,Chrom &Ca [4]
22 ALL M 8 mo Yes Died No A,B 46,XX,t(8;9;12)(p12;q34;p13) na 3’ABL1 on 12p na Zuna et al., 2010 Genes,Chrom & Ca [4]
23 ALL F 8 Yes CR( >10 M) na A,B 46.XX na 3’ABL1 on 12p? na Malone A et al., 2010 Br J Haematol [6]
24 CML M 36 Yes CR(>5Y) No   46,XY, t(9;12)(q34;p13) na 3’ABL1 on 12p normal UTX, ASXL1, EZH2, TET2 & IDH1/2 Perna et al., 2011 Haematologica [24]
25 T/ALL na na na na na na na na na na Zhou et al., 2012 Annual Haematology [5]
26 T/ALL na na na na na na na na na na Zhou et al., 2012 Annual Haematology [5]
27 AML M 52 No Died Yes B 46,XY[20] 5’-3’ETV6 on 12p 3’ABL1 on 12p normal FLT3, cKit & NPM1 Park J et al., 2013 Acta Haematologica [23]
28 B/ALL F 25 No Died No A,B 46,XX,del(9)(p22), der(10)t(9;10)(q22;p15) 5’-3’ETV6 on 12p 3’ABL1 on 12p na Park J et al., 2013 Acta Haematologica [23]
29 CML F 52 Yes CR > 12 M Yes A,B 46,XX,t(9;12)(q34;p13) 5’ETV6 on 9q34 ABL1 3’/5’ on 9q34 37 CNAs Current study
  1. Abbreviations: ALL Acute lymphoblastic leukemia, AML Acute myeloid leukemia, CML Chronic myeloid leukemia, MPN Myeloproliferative disease, MBC Myeloid blast crisis, LBC Lymphoid blast crisis, F Female, M male, CR Cytogenetic remission, Na not available, CNAs Copy number aberrations.