Genotype-phenotype analysis of recombinant chromosome 4 syndrome: an array-CGH study and literature review

Table 1 Comparison of the clinical features of the present case and ten other reported cases of recombinant chromosome 4

Patients	Sex	Parental inversion	Growth retardation	Micro-cephaly	Pointed chin	Broad nose	Thin upper lips	Abnormal ears	Short neck	Broad chest	Cardio-pathy	Genital anomaly
1974 (10)	F	p13q35	+	+	+	+	+	+	+	+	+	-
1974 (11)	M	p14q35	+	+	+	+	+	+	+	+	+	+
1992 (12)	F	p14q35.2	nr	+	+	+	+	+	+	+	nr	nr
1993 (13)	F	p15.32q35	nr	nr	nr	nr	nr	+	nr	nr	nr	nr
2000 (14)	F	p16q35.1	+	+	+	+	+	+	+	nr	nr	-
2002 (15)	M	p14q35	+	+	+	+	+	+	+	+	+	+
2002 (7)	F	p15q35	+	+	+	+	+	+	+	+	+	-
2007 (16)	F	p14q35	+	+	+	+	+	+	+	+	-	-
2007 (16)	F	p14q35	-	+	+	+	+	+	+	+	-	-
2009 (21)	M	p15.1q35	+	-	+	+	+	+	+	+	+	+
our case	M	p15.1q35	+	+	+	+	+	+	+	+	+	+

ISSN: 1755-8166