Figure 2
From: A recurrent translocation is mediated by homologous recombination between HERV-H elements
HERV-H elements from chromosomes 4q and 18q, as compared to the intact HERV-H consensus sequence. The HERV-H consensus is 8657 bp as represented in RepeatMasker [40]. HERVs and long terminal repeats (LTRs) are depicted as open and filled black rectangles, respectively. The 18q HERV-H sequence is derived from Build 36.1 (hg18) of the human genome assembly. HERV-H sequences from the 4qA and 4qB alleles were derived from 18q-82P. Sequence identity between the 4q and 18q HERV-Hs are shown across aligning segments. The 61-bp tandem repeats are represented as dark grey rectangles within the HERV-Hs. Sites of recombination between 4q and 18q that gave rise to translocations in 18q-82C and 18q-146C are shown as vertical grey lines.