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Table 2 Array-CGH and FISH findings in patients

From: Chromosomal Aberrations in ETV6/RUNX1-positive Childhood Acute Lymphoblastic Leukemia using 244K Oligonucleotide Array Comparative Genomic Hybridization

Case No. Array CGH result Significant genes affected FISH result
1 Loss of 12p13 (ETV6), no loss on RUNX1 Loss of ETV6 Rr, 1F - 92%
2 Loss of 12p13 (ETV6); no gain on RUNX1 Loss of PAX5, ETV6, KRAS NA
3 Loss of 12p13 (ETV6); no gain on RUNX1 Loss of MLLT3, CDKN2A/B, MTAP, NOTCH1, BTG1, ETV6 3R, 1F - 55% 2R, 1F - 39%
4 Loss of ETV6 or RUNX1 was not found Loss of MYB, JAK2, MLLT3, CDKN2A/B, MTAP NA
5 Loss of 12p13 (ETV6); no loss on RUNX1 Loss of ETV6 Rr, 1F - 95%
6 Loss of ETV6 or RUNX1 was not found Loss of MYB, MTAP, CDKN2A/B, 2F, Rr, 1G - 60% Rr, 1F, 1G - 37%
7 Loss of 12p13 (ETV6); no gain on RUNX1 Loss of MTAP, CDKN2A/B, ETV6, FHIT NA
8 Loss of ETV6 or RUNX1 was not found Appears normal NA
9 Loss of ETV6 or RUNX1 was not found Appears normal Rr, 1G, 1F - 100%
10 Loss of ETV6 or RUNX1 was not found Appears normal NA
11 Loss of 21q22 (RUNX1); no loss on ETV6 Loss of RUNX1 NA
  1. F = Fusion (ETV6-RUNX1 fusion); R = Red (normal RUNX1 gene); r = residual red (residual RUNX1 gene disrupted by the translocation); G = Green (ETV6 gene).