Figure 1

Ideograms of the normal chromosome 21, and of the rearranged 21s. The der(21) of patient 1 (A), and the inv(21) of patient 2 (B), summarizing the most informative FISH results. The following symbols represent the probes related to RUNX1 sequences used, and the corresponding exons are indicated in the figure, with signals present, not present or weak: # WI2-1915K14, CTD-2349F18,
WI2-942D2,
WI2-605D9,
CTD-2235K24,
WI2-847D7,
WI2-542L2,
weak signal, NP signal not present. The other BAC probes used and mentioned in the text, but not related to RUNX1 sequences, are shown in the figure with other symbols