Figure 3

Extent and gene (RefSeq) content of chromosome 6p22-p24 deletions. Labeling of horizontal bars representing deletions described in the literature are as follows: A, [25]; B, [24]; C, P1 from [23]; D, P2 from [23]; E, 91-145 from [4]; F, 95-800 from [4]; G, PF from [4]; H, [13]; I, AU010604 from [34]; J, [26]; K, [22]; and L, DECIPHER patient ID 249613 [39]. Blue regions depict the maximum extents of the deletions. Longest gene isoforms are shown. Histone gene cluster on 6p22.1-p22.2 is not depicted due to space limitations. Gene names are positioned below or to the left of genes. Green bars represent individuals from the literature, who were reported to have ASDs. Gene names in blue represent strong candidates for ASDs or autistic features given their role in the brain function and development or involvement in neurological disorders (see Table 2). Red vertical bar depicts the smallest deletion overlap, involving 13 deletions (patients 1-3, 5, 6, A-E, G, J, and K). There are four RefSeq genes in this region: ATXN1, FLJ23152, RBM24, and CAP 2. See Table 2 for gene functions. Pt, patient.