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Table 2 Cut off values (median probe signal ±2 SD) for the different probes in the MLPA kits P181, P182, P036B and P070

From: Multiplex ligation dependent probe amplification (MLPA) for rapid distinction between unique sequence positive and negative marker chromosomes in prenatal diagnosis

Probes P181

Cut off values (N = 95)

Probes P182

Cut off values (N = 91)

 

Minimum

Maximum

 

Minimum

Maximum

3p11.2 EPHA3

0,923

1,077

3p11.2 EPHA3

0,923

1,077

3q11.2 PROS1

0,907

1,093

3q11.2 PROS1

0,913

1,087

4p11 OCIAD1

0,880

1,114

4p11 OCIAD1

0,880

1,114

4q12 SGCB

0,946

1,054

4q12 USP46

0,919

1,081

9p13.2 IGFBPL1

0,902

1,098

9p11 EXOSC3

0,940

1,060

9q13 TJP2

0,933

1,067

9q13 TJP2

0,909

1,079

12p11.21 PKP2

0,888

1,112

12p11.21 PKP2

0,894

1,090

12q12 KIF21A

0,899

1,101

12q12 KIF21A

0,886

1,114

13q11 HSMPP8

0,881

1,119

13q11 HSMPP8

0,924

1,060

13q11 ZNF198

0,930

1,066

13q11 ZNF198

0,881

1,119

14q11.2 ADPRTL2

0,863

1,115

14q11.2 ADPRTL2

0,913

1,079

14q11.2 APEX

0,917

1,083

14q11.2 APEX

0,932

1,066

15q11.2 NIPA2

0,883

1,097

15q11.2 NIPA2

0,864

1,128

15q11.2 NDN

0,916

1,078

15q11.2 MKRN3

0,874

1,126

16p11.2 TGFB1I1

0,882

1,098

16p11.2 ERAF

0,927

1,071

16q12 ORC6L

0,914

1,086

16q12 VPS35

0,899

1,101

17p11.2 MAP2K3

0,934

1,064

17p11.2 MAP2K3

0,828

1,170

17q11.1 WSB1

0,927

1,073

17q11.1 WSB1

0,931

1,069

20p11.2 PYGB

0,894

1,102

20p11.21 ZNF337

0,914

1,086

20q11.21 DUSP15

0,912

1,088

20q11.21 REM1

0,893

1,075

21q11 STCH

0,911

1,089

21q11 STCH

0,896

1,104

21q11 SAMSN1

0,861

1,153

21q11 SAMSN1

0,889

1,111

22q11.2 CECR5

0,872

1,086

22q11.2 CECR1

0,877

1,083

22q11.2 CECR1

0,901

1,089

22q11.2 SLC25A18

0,916

1,084

Probes P036B

Cut off values (N = 104)

Probes P070

Cut off values (N = 105)

 

Minimum

Maximum

 

Minimum

Maximum

3p CHL1

0.890

1.110

3p CHL1

0.916

1.080

3q BDH

0.905

1.092

3q KIAA0226

0.933

1.067

4p FLJ20265

0.900

1.101

4p ZNF141

0.828

1.172

4q FRG1

0.744

1.239

4q FRG1

0.865

1.143

9p DMRT1

0.897

1.103

9p FLJ00026

0.915

1.083

9q MRPL41

0.847

1.148

9q EU-HMTase1

0.935

1.065

12p SLC6A12

0.947

1.053

12p RBBP2

0.937

1.063

12q ZNF10

0.858

1.126

12q ZNF10

0.909

1.091

13p PSPC1

0.914

1.074

13p PSPC1

0.900

1.116

13q F7

0.883

1.116

13q CDC16

0.923

1.073

14p HEI10

0.919

1.081

14p ADPRTL2

0.929

1.071

14q MTA1

0.859

1.143

14q MTA1

0.906

1.094

15p CYFIP1

0.925

1.075

15p NDN

0.908

1.092

15q ALDH1A3

0.890

1.110

15q FLJ22604

0.938

1.062

16p POLR3K

0.894

1.108

16p DECR2

0.828

1.178

16q GAS11/GAS8

0.894

1.106

16q GAS11

0.936

1.060

17p RPH3AL

0.901

1.099

17p RPH3AL

0.843

1.163

17q TBCD

0.888

1.108

17q SECTM1

0.890

1.096

20p SOX12

0.843

1.157

20p FLJ22115

0.888

1.112

20q OPRL1

0.866

1.134

20q FLJ20517

0.883

1.117

21p RBM11

0.879

1.121

21p STCH

0.894

1.132

21q HMT1

0.853

1.147

21q S100B

0.921

1.065

22p BID

0.894

1.094

22p IL17R

0.837

1.163

22q RABL2B

0.875

1.127

22q ARSA

0.904

1.096

  1. Only the chromosomes from which the sSMC in this paper are derived, are indicated.
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Molecular Cytogenetics

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