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Table 2 Cut off values (median probe signal ±2 SD) for the different probes in the MLPA kits P181, P182, P036B and P070

From: Multiplex ligation dependent probe amplification (MLPA) for rapid distinction between unique sequence positive and negative marker chromosomes in prenatal diagnosis

Probes P181 Cut off values (N = 95) Probes P182 Cut off values (N = 91)
  Minimum Maximum   Minimum Maximum
3p11.2 EPHA3 0,923 1,077 3p11.2 EPHA3 0,923 1,077
3q11.2 PROS1 0,907 1,093 3q11.2 PROS1 0,913 1,087
4p11 OCIAD1 0,880 1,114 4p11 OCIAD1 0,880 1,114
4q12 SGCB 0,946 1,054 4q12 USP46 0,919 1,081
9p13.2 IGFBPL1 0,902 1,098 9p11 EXOSC3 0,940 1,060
9q13 TJP2 0,933 1,067 9q13 TJP2 0,909 1,079
12p11.21 PKP2 0,888 1,112 12p11.21 PKP2 0,894 1,090
12q12 KIF21A 0,899 1,101 12q12 KIF21A 0,886 1,114
13q11 HSMPP8 0,881 1,119 13q11 HSMPP8 0,924 1,060
13q11 ZNF198 0,930 1,066 13q11 ZNF198 0,881 1,119
14q11.2 ADPRTL2 0,863 1,115 14q11.2 ADPRTL2 0,913 1,079
14q11.2 APEX 0,917 1,083 14q11.2 APEX 0,932 1,066
15q11.2 NIPA2 0,883 1,097 15q11.2 NIPA2 0,864 1,128
15q11.2 NDN 0,916 1,078 15q11.2 MKRN3 0,874 1,126
16p11.2 TGFB1I1 0,882 1,098 16p11.2 ERAF 0,927 1,071
16q12 ORC6L 0,914 1,086 16q12 VPS35 0,899 1,101
17p11.2 MAP2K3 0,934 1,064 17p11.2 MAP2K3 0,828 1,170
17q11.1 WSB1 0,927 1,073 17q11.1 WSB1 0,931 1,069
20p11.2 PYGB 0,894 1,102 20p11.21 ZNF337 0,914 1,086
20q11.21 DUSP15 0,912 1,088 20q11.21 REM1 0,893 1,075
21q11 STCH 0,911 1,089 21q11 STCH 0,896 1,104
21q11 SAMSN1 0,861 1,153 21q11 SAMSN1 0,889 1,111
22q11.2 CECR5 0,872 1,086 22q11.2 CECR1 0,877 1,083
22q11.2 CECR1 0,901 1,089 22q11.2 SLC25A18 0,916 1,084
Probes P036B Cut off values (N = 104) Probes P070 Cut off values (N = 105)
  Minimum Maximum   Minimum Maximum
3p CHL1 0.890 1.110 3p CHL1 0.916 1.080
3q BDH 0.905 1.092 3q KIAA0226 0.933 1.067
4p FLJ20265 0.900 1.101 4p ZNF141 0.828 1.172
4q FRG1 0.744 1.239 4q FRG1 0.865 1.143
9p DMRT1 0.897 1.103 9p FLJ00026 0.915 1.083
9q MRPL41 0.847 1.148 9q EU-HMTase1 0.935 1.065
12p SLC6A12 0.947 1.053 12p RBBP2 0.937 1.063
12q ZNF10 0.858 1.126 12q ZNF10 0.909 1.091
13p PSPC1 0.914 1.074 13p PSPC1 0.900 1.116
13q F7 0.883 1.116 13q CDC16 0.923 1.073
14p HEI10 0.919 1.081 14p ADPRTL2 0.929 1.071
14q MTA1 0.859 1.143 14q MTA1 0.906 1.094
15p CYFIP1 0.925 1.075 15p NDN 0.908 1.092
15q ALDH1A3 0.890 1.110 15q FLJ22604 0.938 1.062
16p POLR3K 0.894 1.108 16p DECR2 0.828 1.178
16q GAS11/GAS8 0.894 1.106 16q GAS11 0.936 1.060
17p RPH3AL 0.901 1.099 17p RPH3AL 0.843 1.163
17q TBCD 0.888 1.108 17q SECTM1 0.890 1.096
20p SOX12 0.843 1.157 20p FLJ22115 0.888 1.112
20q OPRL1 0.866 1.134 20q FLJ20517 0.883 1.117
21p RBM11 0.879 1.121 21p STCH 0.894 1.132
21q HMT1 0.853 1.147 21q S100B 0.921 1.065
22p BID 0.894 1.094 22p IL17R 0.837 1.163
22q RABL2B 0.875 1.127 22q ARSA 0.904 1.096
  1. Only the chromosomes from which the sSMC in this paper are derived, are indicated.
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Molecular Cytogenetics

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